基于线粒体DNA控制区数据对巴基斯坦马克拉尼人群的遗传学特征分析
Genetic characterization of the Makrani people of Pakistan from mitochondrial DNA control-region data.
作者信息
Siddiqi Muhammad Hassan, Akhtar Tanveer, Rakha Allah, Abbas Ghazanfar, Ali Akram, Haider Naeem, Ali Azam, Hayat Sikandar, Masooma Syeda, Ahmad Jamil, Tariq Muhammad Akram, van Oven Mannis, Khan Fazle Majid
机构信息
Department of Zoology, University of the Punjab, Lahore 54590, Pakistan.
Department of Zoology, University of the Punjab, Lahore 54590, Pakistan.
出版信息
Leg Med (Tokyo). 2015 Mar;17(2):134-9. doi: 10.1016/j.legalmed.2014.09.007. Epub 2014 Oct 13.
To estimate genetic and forensic parameters, the entire mitochondrial DNA control region of 100 unrelated Makrani individuals (males, n=96; females, n=4) living in Pakistan (Turbat, Panjgur, Awaran, Kharan, Nasirabad, Gwadar, Buleda, Karachi and Burewala) was sequenced. We observed a total of 70 different haplotypes of which 54 were unique and 16 were shared by more than one individual. The Makrani population showed a high genetic diversity (0.9688) and, consequently, a high power of discrimination (0.9592). Our results revealed a strongly admixed mtDNA pool composed of African haplogroups (28%), West Eurasian haplogroups (26%), South Asian haplogroups (24%), and East Asian haplogroups (2%), while the origin of the remaining individuals (20%) could not be confidently assigned. The results of this study are a valuable contribution to build a database of mtDNA variation in Pakistan.
为了估计遗传和法医参数，我们对生活在巴基斯坦（图尔巴特、潘杰古尔、阿瓦兰、哈兰、纳西拉巴德、瓜达尔、布雷达、卡拉奇和布勒瓦拉）的100名无亲缘关系的马克拉尼个体（男性，n = 96；女性，n = 4）的整个线粒体DNA控制区进行了测序。我们共观察到70种不同的单倍型，其中54种是独特的，16种为多个个体所共有。马克拉尼人群显示出较高的遗传多样性（0.9688），因此，具有较高的鉴别力（0.9592）。我们的结果揭示了一个高度混合的线粒体DNA库，其中包括非洲单倍群（28%）、西欧亚单倍群（26%）、南亚单倍群（24%）和东亚单倍群（2%），而其余个体（20%）的起源无法确定。本研究结果为建立巴基斯坦线粒体DNA变异数据库做出了宝贵贡献。
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