Devine Eric G, Knapp Clifford M, Sarid-Segal Ofra, O'Keefe Sean M, Wardell Cale, Baskett Morgan, Pecchia Ashley, Ferrell Katie, Ciraulo Domenic A
Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Contemp Clin Trials. 2015 Mar;41:55-61. doi: 10.1016/j.cct.2014.12.004. Epub 2014 Dec 18.
Multiple models guide researchers' payment practices but few studies have assessed subjects' expectations for payment. Payments in excess of subjects' expectations may result in undue inducement, while payments below these expectations may be associated with exploitation. Data on subjects' payment expectations will help inform practices to avoid undue inducement and exploitation. This study examined subjects' expectations for payment for common research procedures and explored the relationship between subjects' honesty and payment expectations. One-hundred subjects who participated in two or more studies in the last year reported the minimum payment they expect for completing study procedures. They were also asked about their use of deception while screening for studies. Subjects expected $20 on average to complete the least risky and least burdensome procedure. Subjects' expectations for payment consistently increased with greater procedure risks. Subjects who denied using deception to enroll in studies refused more procedures than subjects who reported using deception. Among subjects who used deception, the rate of procedure refusal increased with procedure risks, suggesting that these subjects have some risk aversion and may act to protect themselves from undue inducement. Although subjects expect greater payments for more risky procedures, ethical considerations for limiting undue inducement may prevent researchers from meeting subjects' expectations. Subjects who use deceptive practices appear to be more risk-tolerant than subjects who deny using deception; nonetheless, these deceptive subjects also exercise some risk aversion when they refuse higher-risk procedures. These subjects may be able to protect themselves from undue inducement by refusing procedures that exceed their risk tolerance.
多种模式指导研究人员的支付行为,但很少有研究评估受试者对报酬的期望。支付金额超过受试者的期望可能会导致不当诱导,而低于这些期望的支付可能与剥削有关。关于受试者支付期望的数据将有助于为避免不当诱导和剥削的行为提供信息。本研究考察了受试者对常见研究程序报酬的期望,并探讨了受试者的诚实与支付期望之间的关系。去年参与两项或更多项研究的100名受试者报告了他们完成研究程序期望获得的最低报酬。他们还被问及在筛选研究时是否使用欺骗手段。受试者完成风险最低、负担最轻的程序平均期望获得20美元。受试者对报酬的期望随着程序风险的增加而持续上升。否认在参加研究时使用欺骗手段的受试者比报告使用欺骗手段的受试者拒绝更多的程序。在使用欺骗手段的受试者中,程序拒绝率随着程序风险的增加而上升,这表明这些受试者有一定的风险规避意识,可能会采取行动保护自己免受不当诱导。尽管受试者期望对风险更高的程序支付更多报酬,但限制不当诱导的伦理考量可能会阻止研究人员满足受试者的期望。使用欺骗行为的受试者似乎比否认使用欺骗行为的受试者更能容忍风险;尽管如此,这些使用欺骗手段的受试者在拒绝高风险程序时也会表现出一定的风险规避。这些受试者可能能够通过拒绝超出其风险承受能力的程序来保护自己免受不当诱导。