蚊子基因组学。高度可进化的疟疾传播媒介：16种按蚊的基因组
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
作者信息
Neafsey Daniel E, Waterhouse Robert M, Abai Mohammad R, Aganezov Sergey S, Alekseyev Max A, Allen James E, Amon James, Arcà Bruno, Arensburger Peter, Artemov Gleb, Assour Lauren A, Basseri Hamidreza, Berlin Aaron, Birren Bruce W, Blandin Stephanie A, Brockman Andrew I, Burkot Thomas R, Burt Austin, Chan Clara S, Chauve Cedric, Chiu Joanna C, Christensen Mikkel, Costantini Carlo, Davidson Victoria L M, Deligianni Elena, Dottorini Tania, Dritsou Vicky, Gabriel Stacey B, Guelbeogo Wamdaogo M, Hall Andrew B, Han Mira V, Hlaing Thaung, Hughes Daniel S T, Jenkins Adam M, Jiang Xiaofang, Jungreis Irwin, Kakani Evdoxia G, Kamali Maryam, Kemppainen Petri, Kennedy Ryan C, Kirmitzoglou Ioannis K, Koekemoer Lizette L, Laban Njoroge, Langridge Nicholas, Lawniczak Mara K N, Lirakis Manolis, Lobo Neil F, Lowy Ernesto, MacCallum Robert M, Mao Chunhong, Maslen Gareth, Mbogo Charles, McCarthy Jenny, Michel Kristin, Mitchell Sara N, Moore Wendy, Murphy Katherine A, Naumenko Anastasia N, Nolan Tony, Novoa Eva M, O'Loughlin Samantha, Oringanje Chioma, Oshaghi Mohammad A, Pakpour Nazzy, Papathanos Philippos A, Peery Ashley N, Povelones Michael, Prakash Anil, Price David P, Rajaraman Ashok, Reimer Lisa J, Rinker David C, Rokas Antonis, Russell Tanya L, Sagnon N'Fale, Sharakhova Maria V, Shea Terrance, Simão Felipe A, Simard Frederic, Slotman Michel A, Somboon Pradya, Stegniy Vladimir, Struchiner Claudio J, Thomas Gregg W C, Tojo Marta, Topalis Pantelis, Tubio José M C, Unger Maria F, Vontas John, Walton Catherine, Wilding Craig S, Willis Judith H, Wu Yi-Chieh, Yan Guiyun, Zdobnov Evgeny M, Zhou Xiaofan, Catteruccia Flaminia, Christophides George K, Collins Frank H, Cornman Robert S, Crisanti Andrea, Donnelly Martin J, Emrich Scott J, Fontaine Michael C, Gelbart William, Hahn Matthew W, Hansen Immo A, Howell Paul I, Kafatos Fotis C, Kellis Manolis, Lawson Daniel, Louis Christos, Luckhart Shirley, Muskavitch Marc A T, Ribeiro José M, Riehle Michael A, Sharakhov Igor V, Tu Zhijian, Zwiebel Laurence J, Besansky Nora J
机构信息
Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland.
出版信息
Science. 2015 Jan 2;347(6217):1258522. doi: 10.1126/science.1258522. Epub 2014 Nov 27.
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
按蚊种类之间人类疟疾传播能力的差异由许多因素决定，包括行为、免疫力和生活史。为了研究传播能力的基因组基础并探索新的病媒控制途径，我们对来自不同地点、跨越约1亿年进化历程的16种按蚊的基因组进行了测序。比较分析表明，相对于果蝇，按蚊的基因获得和丢失速率更快，X染色体上的基因重排增加，内含子丢失更多。一些传播能力的决定因素，如化学感应基因，并没有显示出更高的更新率，而是通过蛋白质序列变化实现多样化。按蚊基因和基因组的这种动态变化可能有助于它们灵活地利用新的生态位，包括适应人类作为主要宿主。
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