一种用于3D打印可调节、细胞兼容水凝胶的多材料生物墨水方法。
A multimaterial bioink method for 3D printing tunable, cell-compatible hydrogels.
作者信息
Rutz Alexandra L, Hyland Kelly E, Jakus Adam E, Burghardt Wesley R, Shah Ramille N
机构信息
Simpson Querrey Institute for BioNanotechnology, Chicago, IL, 60611, USA; Department of Biomedical Engineering, Evanston, IL, 60208, USA.
出版信息
Adv Mater. 2015 Mar 4;27(9):1607-14. doi: 10.1002/adma.201405076. Epub 2015 Jan 16.
Abstract
A multimaterial bio-ink method using polyethylene glycol crosslinking is presented for expanding the biomaterial palette required for 3D bioprinting of more mimetic and customizable tissue and organ constructs. Lightly crosslinked, soft hydrogels are produced from precursor solutions of various materials and 3D printed. Rheological and biological characterizations are presented, and the promise of this new bio-ink synthesis strategy is discussed.
摘要
提出了一种使用聚乙二醇交联的多材料生物墨水方法，以扩展3D生物打印更具模拟性和可定制性的组织和器官构建体所需的生物材料库。由各种材料的前体溶液制备轻度交联的软水凝胶并进行3D打印。给出了流变学和生物学表征，并讨论了这种新的生物墨水合成策略的前景。
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