通过协同光氧化还原和路易斯酸催化实现α-氨基自由基的对映选择性共轭加成反应。
Enantioselective conjugate additions of α-amino radicals via cooperative photoredox and Lewis acid catalysis.
作者信息
Ruiz Espelt Laura, McPherson Iain S, Wiensch Eric M, Yoon Tehshik P
机构信息
Department of Chemistry, University of Wisconsin-Madison , 1101 University Avenue, Madison, Wisconsin 53706, United States.
出版信息
J Am Chem Soc. 2015 Feb 25;137(7):2452-5. doi: 10.1021/ja512746q. Epub 2015 Feb 16.
Abstract
We report the highly enantioselective addition of photogenerated α-amino radicals to Michael acceptors. This method features a dual-catalyst protocol that combines transition metal photoredox catalysis with chiral Lewis acid catalysis. The combination of these two powerful modes of catalysis provides an effective, general strategy to generate and control the reactivity of photogenerated reactive intermediates.
摘要
我们报道了光生α-氨基自由基对迈克尔受体的高度对映选择性加成反应。该方法采用双催化剂体系，将过渡金属光氧化还原催化与手性路易斯酸催化相结合。这两种强大催化模式的结合提供了一种有效且通用的策略，用于生成和控制光生反应中间体的反应活性。
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