G蛋白偶联雌激素受体在糖尿病和动脉粥样硬化中的新作用
Emerging roles of GPER in diabetes and atherosclerosis.
作者信息
Barton Matthias, Prossnitz Eric R
机构信息
Molecular Internal Medicine, University of Zurich, Switzerland.
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA; UNM Cancer Center, University of New Mexico Health Sciences Center, Albuquerque, NM 87120, USA.
出版信息
Trends Endocrinol Metab. 2015 Apr;26(4):185-92. doi: 10.1016/j.tem.2015.02.003. Epub 2015 Mar 9.
The G protein-coupled estrogen receptor (GPER) is a 7-transmembrane receptor implicated in rapid estrogen signaling. Originally cloned from vascular endothelial cells, GPER plays a central role in the regulation of vascular tone and cell growth as well as lipid and glucose homeostasis. This review highlights our knowledge of the physiological and pathophysiological functions of GPER in the pancreas, peripheral and immune tissues, and the arterial vasculature. Recent findings on its roles in obesity, diabetes, and atherosclerosis, including GPER-dependent regulation of lipid metabolism and inflammation, are presented. The therapeutic potential of targeting GPER-dependent pathways in chronic diseases such as coronary artery disease and diabetes and in the context of menopause is also discussed.
G蛋白偶联雌激素受体（GPER）是一种参与快速雌激素信号传导的7次跨膜受体。GPER最初从血管内皮细胞中克隆出来，在血管张力调节、细胞生长以及脂质和葡萄糖稳态中发挥核心作用。本综述重点介绍了我们对GPER在胰腺、外周组织和免疫组织以及动脉血管系统中的生理和病理生理功能的认识。文中介绍了其在肥胖、糖尿病和动脉粥样硬化中的最新作用，包括GPER对脂质代谢和炎症的依赖性调节。还讨论了在冠状动脉疾病和糖尿病等慢性疾病以及绝经背景下，靶向GPER依赖性途径的治疗潜力。
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