横纹肌溶解症：发病机制、诊断与治疗
Rhabdomyolysis: pathogenesis, diagnosis, and treatment.
作者信息
Torres Patrick A, Helmstetter John A, Kaye Adam M, Kaye Alan David
机构信息
Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA.
Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA.
出版信息
Ochsner J. 2015 Spring;15(1):58-69.
Abstract
BACKGROUND
Rhabdomyolysis is a complex medical condition involving the rapid dissolution of damaged or injured skeletal muscle.
METHODS
This review focuses on the epidemiology, pathophysiology, causes, presentation, diagnosis, complications, management, and anesthetic considerations related to rhabdomyolysis.
RESULTS
Any form of muscle damage--and by extension any entity that causes muscle damage--can initiate rhabdomyolysis. One of the most important treatment goals when rhabdomyolysis is suspected is avoiding acute kidney injury.
CONCLUSION
All clinicians should be aware of common causes, diagnosis, and treatment options.
摘要
背景
横纹肌溶解症是一种复杂的医学病症，涉及受损或受伤骨骼肌的快速溶解。
方法
本综述聚焦于与横纹肌溶解症相关的流行病学、病理生理学、病因、临床表现、诊断、并发症、治疗及麻醉注意事项。
结果
任何形式的肌肉损伤——进而任何导致肌肉损伤的因素——都可引发横纹肌溶解症。怀疑发生横纹肌溶解症时，最重要的治疗目标之一是避免急性肾损伤。
结论
所有临床医生都应了解其常见病因、诊断方法及治疗选择。
相似文献
1
Rhabdomyolysis: pathogenesis, diagnosis, and treatment.
Ochsner J. 2015 Spring;15(1):58-69.
2
Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury.
Nat Med. 2018 Feb;24(2):232-238. doi: 10.1038/nm.4462. Epub 2018 Jan 8.
3
Rhabdomyolysis.
Chest. 2013 Sep;144(3):1058-1065. doi: 10.1378/chest.12-2016.
4
[Rhabdomyolysis: have you considered food poisoning from quails?].
G Ital Nefrol. 2020 Apr 9;37(2):2020-vol2.
5
Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.
Clin Biochem. 2017 Aug;50(12):656-662. doi: 10.1016/j.clinbiochem.2017.02.016. Epub 2017 Feb 21.
6
The other medical causes of rhabdomyolysis.
Am J Med Sci. 2003 Aug;326(2):79-88. doi: 10.1097/00000441-200308000-00005.
7
Drugs and Rhabdomyolysis: From Liver to Kidney.
Curr Vasc Pharmacol. 2015;13(6):725-37. doi: 10.2174/1570161113666150130151839.
8
Rhabdomyolysis-Induced Acute Kidney Injury in Diabetic Emergency: Underdiagnosed and an Important Association to Be Aware of.
Case Rep Med. 2018 Oct 31;2018:4132738. doi: 10.1155/2018/4132738. eCollection 2018.
9
From quail to earthquakes and human conflict: a historical perspective of rhabdomyolysis.
Clin Kidney J. 2020 May 22;14(4):1088-1096. doi: 10.1093/ckj/sfaa075. eCollection 2021 Apr.
10
Pediatric Rhabdomyolysis.
Pediatr Rev. 2020 Jun;41(6):265-275. doi: 10.1542/pir.2018-0300.
引用本文的文献
1
Crush Syndrome and Systemic Necrosis in Trauma Patients: A Systematic Review of Pathophysiology, Anatomical Impact, and Renal Outcomes.
Cureus. 2025 Aug 7;17(8):e89592. doi: 10.7759/cureus.89592. eCollection 2025 Aug.
2
Increased risk of rhabdomyolysis in patients using statins: a population-based case-control study.
Ther Adv Drug Saf. 2025 Aug 11;16:20420986251365746. doi: 10.1177/20420986251365746. eCollection 2025.
3
Exertional Rhabdomyolysis and Ultra-Trail Races: A Systematic Review Highlighting the Significant Impact of Eccentric Load.
Muscles. 2024 Aug 13;3(3):242-258. doi: 10.3390/muscles3030022.
4
Impact of Rhabdomyolysis on Clinical Outcomes in Patients With Acute Myocardial Infarction.
Cureus. 2025 Jul 1;17(7):e87142. doi: 10.7759/cureus.87142. eCollection 2025 Jul.
5
Acute Rhabdomyolysis as a Rare Manifestation of Hypothyroidism: A Case Report and Literature Review.
Cureus. 2025 Jun 24;17(6):e86675. doi: 10.7759/cureus.86675. eCollection 2025 Jun.
6
Serum Concentrations of Imidazole Dipeptides and Serum Amyloid A in a Bottlenose Dolphin () with Rhabdomyolysis: Potential Biomarkers for Muscular Damage.
Animals (Basel). 2025 Jul 2;15(13):1950. doi: 10.3390/ani15131950.
7
Severe rhabdomyolysis induced by bezafibrate in the treatment of severe acute pancreatitis with hyperlipidemia: A case report.
Medicine (Baltimore). 2025 Jun 27;104(26):e43009. doi: 10.1097/MD.0000000000043009.
8
Time-to-Onset Analysis of Rhabdomyolysis Associated With Selective Serotonin and Serotonin-Noradrenaline Reuptake Inhibitors Using the Japanese Pharmacovigilance Database.
In Vivo. 2025 Jul-Aug;39(4):2115-2122. doi: 10.21873/invivo.14007.
9
Dermatomyositis, Rhabdomyolysis, and Statin-Induced Myopathy: A Case Report Illustrating the Spectrum of Myopathy.
Cureus. 2025 May 26;17(5):e84854. doi: 10.7759/cureus.84854. eCollection 2025 May.
10
The Hidden Hazard of Hypothyroidism: Statin-Associated Rhabdomyolysis With Life-Threatening Complications.
Cureus. 2025 Jun 7;17(6):e85506. doi: 10.7759/cureus.85506. eCollection 2025 Jun.
本文引用的文献
1
Anesthesia and Duchenne or Becker muscular dystrophy: review of 117 anesthetic exposures.
Paediatr Anaesth. 2013 Sep;23(9):855-64. doi: 10.1111/pan.12248. Epub 2013 Aug 6.
2
Cytochrome P450 drug interactions with statin therapy.
Singapore Med J. 2013 Mar;54(3):131-5. doi: 10.11622/smedj.2013044.
3
The controversies of statin therapy: weighing the evidence.
J Am Coll Cardiol. 2012 Sep 4;60(10):875-81. doi: 10.1016/j.jacc.2012.07.007. Epub 2012 Aug 15.
4
Anaesthetic management in patients with Duchenne muscular dystrophy undergoing orthopaedic surgery: a review of 232 cases.
Eur J Anaesthesiol. 2012 Oct;29(10):489-94. doi: 10.1097/EJA.0b013e3283566789.
5
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.
J Clin Neuromuscul Dis. 2012 Mar;13(3):122-36. doi: 10.1097/CND.0b013e31822721ca.
6
Clinical importance of the drug interaction between statins and CYP3A4 inhibitors: a retrospective cohort study in The Health Improvement Network.
Pharmacoepidemiol Drug Saf. 2012 May;21(5):494-506. doi: 10.1002/pds.3199. Epub 2012 Mar 16.
7
Statin-induced myopathies.
Pharmacol Rep. 2011;63(4):859-66. doi: 10.1016/s1734-1140(11)70601-6.
8
Statin myopathy: a common dilemma not reflected in clinical trials.
Cleve Clin J Med. 2011 Jun;78(6):393-403. doi: 10.3949/ccjm.78a.10073.
9
Early fluid resuscitation in patients with rhabdomyolysis.
Nat Rev Nephrol. 2011 May 17;7(7):416-22. doi: 10.1038/nrneph.2011.56.
10
Rhabdomyolysis: pathogenesis of renal injury and management.
Pediatr Nephrol. 2011 Oct;26(10):1781-8. doi: 10.1007/s00467-010-1727-3. Epub 2011 Jan 20.
Zotero 插件