超越癌症的3D培养模型。
Beyond 3D culture models of cancer.
作者信息
Tanner Kandice, Gottesman Michael M
机构信息
Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Sci Transl Med. 2015 Apr 15;7(283):283ps9. doi: 10.1126/scitranslmed.3009367.
Abstract
The mechanisms underlying the spatiotemporal evolution of tumor ecosystems present a challenge in evaluating drug efficacy. In this Perspective, we address the use of three-dimensional in vitro culture models to delineate the dynamic interplay between the tumor and the host microenvironment in an effort to attain realistic platforms for assessing pharmaceutical efficacy in patients.
摘要
肿瘤生态系统时空演变的潜在机制给评估药物疗效带来了挑战。在本观点文章中，我们探讨了使用三维体外培养模型来描绘肿瘤与宿主微环境之间的动态相互作用，以期获得用于评估患者药物疗效的真实平台。
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