微小RNA-365在肝细胞癌中的预后意义及抗增殖作用
Prognostic significance and anti-proliferation effect of microRNA-365 in hepatocellular carcinoma.
作者信息
Chen Zhizhao, Huang Zufa, Ye Qifa, Ming Yingzi, Zhang Sheng, Zhao Yujun, Liu Lian, Wang Qiang, Cheng Ke
机构信息
Transplantation Center of The Third Xiangya Hospital of Central South University Changsha 410013, China.
出版信息
Int J Clin Exp Pathol. 2015 Feb 1;8(2):1705-11. eCollection 2015.
Abstract
MircroRNA functions as tumor suppressor or promoter in hepatocellular carcinoma (HCC). Researchers have found that miR-365 expression was lower in HCC tissues compared with that in adjacent normal tissues. However, its prognostic significance and anti-proliferation effect in HCC remain to be clarified. In this study, we firstly found that miR-365 expression was lower in HCC tissues compared with that in adjacent normal tissues. Then, we analyzed miR-365 expression level and its clinicopathological and prognostic significance. Finally, overexpression of miR-365 inhibits HCC cell proliferation and migration in vitro. Our findings suggest that miR-365 expression was an independent poor prognostic factor for HCC patient overall survival and suppressed tumor cell growth. Therefore, miR-365 may serve as a valuable prognostic marker and promising target for HCC.
摘要
微小RNA在肝细胞癌（HCC）中发挥着肿瘤抑制或促进作用。研究人员发现，与相邻正常组织相比，HCC组织中miR-365的表达较低。然而，其在HCC中的预后意义和抗增殖作用仍有待阐明。在本研究中，我们首先发现与相邻正常组织相比，HCC组织中miR-365的表达较低。然后，我们分析了miR-365的表达水平及其临床病理和预后意义。最后，miR-365的过表达在体外抑制HCC细胞的增殖和迁移。我们的研究结果表明，miR-365表达是HCC患者总生存的独立不良预后因素，并抑制肿瘤细胞生长。因此，miR-365可能作为HCC的一个有价值的预后标志物和有前景的治疗靶点。
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本文引用的文献
1
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Int J Clin Exp Pathol. 2014 Sep 15;7(10):7286-96. eCollection 2014.
2
A key role of microRNA-29b in suppression of osteosarcoma cell proliferation and migration via modulation of VEGF.
Int J Clin Exp Pathol. 2014 Aug 15;7(9):5701-8. eCollection 2014.
3
Differential effects of targeting Notch receptors in a mouse model of liver cancer.
Hepatology. 2015 Mar;61(3):942-52. doi: 10.1002/hep.27566. Epub 2015 Jan 28.
4
Down-regulation of long non-coding RNA GAS5 is associated with the prognosis of hepatocellular carcinoma.
Int J Clin Exp Pathol. 2014 Jun 15;7(7):4303-9. eCollection 2014.
5
miR-365 promotes cutaneous squamous cell carcinoma (CSCC) through targeting nuclear factor I/B (NFIB).
PLoS One. 2014 Jun 20;9(6):e100620. doi: 10.1371/journal.pone.0100620. eCollection 2014.
6
Cytokeratin 7/19 expression in N-diethylnitrosamine-induced mouse hepatocellular lesions: implications for histogenesis.
Int J Exp Pathol. 2014 Jun;95(3):191-8. doi: 10.1111/iep.12082. Epub 2014 Apr 15.
7
MiR-365 induces gemcitabine resistance in pancreatic cancer cells by targeting the adaptor protein SHC1 and pro-apoptotic regulator BAX.
Cell Signal. 2014 Feb;26(2):179-85. doi: 10.1016/j.cellsig.2013.11.003. Epub 2013 Nov 9.
8
MicroRNA-124 suppresses growth of human hepatocellular carcinoma by targeting STAT3.
Biochem Biophys Res Commun. 2013 Nov 29;441(4):873-9. doi: 10.1016/j.bbrc.2013.10.157. Epub 2013 Nov 6.
9
MicroRNA-365 regulates NKX2-1, a key mediator of lung cancer.
Cancer Lett. 2013 Jul 28;335(2):487-94. doi: 10.1016/j.canlet.2013.03.006. Epub 2013 Mar 16.
10
MicroRNA-101 suppresses SOX9-dependent tumorigenicity and promotes favorable prognosis of human hepatocellular carcinoma.
FEBS Lett. 2012 Dec 14;586(24):4362-70. doi: 10.1016/j.febslet.2012.10.053. Epub 2012 Nov 21.
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