产前多溴联苯醚暴露与出生结局。
Prenatal exposure to polybrominated diphenyl ethers and birth outcomes.
机构信息
Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China; MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Environ Pollut. 2015 Nov;206:32-7. doi: 10.1016/j.envpol.2015.06.019. Epub 2015 Jul 2.
This study aimed to examine the potential association between maternal PBDEs and birth outcomes, including birth weight (g), length (cm), head circumference (cm) and gestational age (week). 215 mothers were recruited from a prospective birth cohort in rural northern China between September 2010 and February 2012. Serum PBDE congeners were detected and their association with birth outcomes were examined. The median maternal serum concentrations of BDE-28, -47, -99, -100, -153 were 2.27, 2.26, 3.58, 2.13, 4.87 ng/g lipid, respectively. Maternal LgBDE-28 and LgBDE-100 were negatively associated with birth length (β = -0.92, 95% confidence interval (CI): -1.82, -0.02; β = -0.97, 95% CI: -1.83, -0.08). A negative association was found between LgBDE-28 and birth weight among male infants (β = -253.76, 95% CI: -438.16, -69.36). PBDE congeners were not associated with head circumference, or gestational age. Our results contribute to growing evidence suggesting that PBDEs have adverse effects on birth outcomes.
本研究旨在探讨母体 PBDEs 与出生结局之间的潜在关联，包括出生体重（g）、身长（cm）、头围（cm）和胎龄（周）。2010 年 9 月至 2012 年 2 月，在中国北方农村的一个前瞻性出生队列中招募了 215 名母亲。检测了血清 PBDE 同系物，并研究了它们与出生结局的关系。母亲血清中 BDE-28、-47、-99、-100、-153 的中位数浓度分别为 2.27、2.26、3.58、2.13、4.87ng/g 脂质。母体 LgBDE-28 和 LgBDE-100 与出生长度呈负相关（β=-0.92，95%置信区间（CI）：-1.82，-0.02；β=-0.97，95%CI：-1.83，-0.08）。LgBDE-28 与男婴的出生体重呈负相关（β=-253.76，95%CI：-438.16，-69.36）。PBDE 同系物与头围或胎龄无关联。我们的结果为越来越多的证据表明 PBDEs 对出生结局有不良影响提供了依据。
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