肉芽肿性药疹

Granulomatous Drug Eruptions.

作者信息

Dodiuk-Gad Roni P, Shear Neil H

机构信息

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Department of Dermatology, Ha'emek Medical Center, Afula 18101, Israel.

Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, 2075 Bayview Ave., Room M1-737, Toronto, ON M4N 3M5, Canada; Division of Clinical Pharmacology and Toxicology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Room M1-737, Toronto, Ontario M4N 3M5, Canada.

出版信息

Dermatol Clin. 2015 Jul;33(3):525-39. doi: 10.1016/j.det.2015.03.015.

DOI:10.1016/j.det.2015.03.015

PMID:26143430

Abstract

Granuloma formation is usually regarded as a means of defending the host from persistent irritants of either exogenous or endogenous origin. Noninfectious granulomatous disorders of the skin encompass a challenging group of diseases owing to their clinical and histologic overlap. Drug reactions characterized by a granulomatous reaction pattern are rare, and defined by a predominance of histiocytes in the inflammatory infiltrate. This review summarizes current knowledge on the various types of granulomatous drug eruptions, focusing on the 4 major types: interstitial granulomatous drug reaction, drug-induced accelerated rheumatoid nodulosis, drug-induced granuloma annulare, and drug-induced sarcoidosis.

摘要

肉芽肿形成通常被视为机体抵御外源性或内源性持续性刺激物的一种方式。皮肤非感染性肉芽肿性疾病因其临床和组织学表现重叠，构成了一组具有挑战性的疾病。以肉芽肿反应模式为特征的药物反应较为罕见，其定义为炎症浸润中组织细胞占优势。本综述总结了目前关于各类肉芽肿性药疹的知识，重点关注4种主要类型：间质性肉芽肿性药物反应、药物性加速类风湿结节病、药物性环状肉芽肿和药物性结节病。