用没食子酸改性的SBA-15介孔二氧化硅及其细胞毒性活性评估
SBA-15 Mesoporous Silica Modified with Gallic Acid and Evaluation of Its Cytotoxic Activity.
作者信息
Lewandowski Dawid, Ruszkowski Piotr, Pińska Anita, Schroeder Grzegorz, Kurczewska Joanna
机构信息
Faculty of Chemistry, Adam Mickiewicz University, Poznan, Poland.
Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland.
出版信息
PLoS One. 2015 Jul 7;10(7):e0132541. doi: 10.1371/journal.pone.0132541. eCollection 2015.
Gallic acid has been covalently conjugated to SBA-15 mesoporous silica surface through different linkers. Cytotoxic activity of the hybrid organic-inorganic systems against HeLa and KB cell lines has been analyzed. Up to 67% of HeLa or KB tumor cells growth inhibition has been achieved at low silica concentration used (10 μg mL(-1)).
没食子酸已通过不同的连接体与SBA - 15介孔二氧化硅表面共价结合。已分析了这种有机 - 无机杂化体系对HeLa和KB细胞系的细胞毒性活性。在低二氧化硅浓度（10μg mL(-1)）下，已实现高达67%的HeLa或KB肿瘤细胞生长抑制。
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