母亲肥胖会增加新生儿的氧化应激。
Maternal obesity increases oxidative stress in the newborn.
作者信息
Gallardo Juan Manuel, Gómez-López Jaqueline, Medina-Bravo Patricia, Juárez-Sánchez Francisco, Contreras-Ramos Alejandra, Galicia-Esquivel Matilde, Sánchez-Urbina Rocío, Klünder-Klünder Miguel
机构信息
Unidad De Investigación Médica En Enfermedades Nefrológicas, Hospital De Especialidades Centro Médico Nacional "Siglo XXI," Instituto Mexicano Del Seguro Social, México City, México.
Hospital De La Mujer, Secretaria De La Defensa Nacional, México City, México.
出版信息
Obesity (Silver Spring). 2015 Aug;23(8):1650-4. doi: 10.1002/oby.21159.
OBJECTIVE
Obesity before pregnancy is associated with a greater risk for the offspring to develop obesity and diabetes in childhood and adulthood. The aim of the present study was to determine the association between maternal overweight or obesity before pregnancy and newborn oxidative stress (OS).
METHODS
Seventy-two mother-child pairs were divided according to the pre-gestational body mass index (BMI) of the mothers as follows: eutrophic (n = 21), overweight (n = 32), and obese (n = 19). Malondialdehyde (MDA) and nitric oxide (NO) were measured in the plasma of a blood sample from the newborn's umbilical cord.
RESULTS
The MDA levels of newborns increased with maternal BMI (P = 0.001), as did the levels of NO (P = 0.019). There was a direct correlation between MDA and NO levels in each of the three groups (eutrophic: R(2) = 0.59, P < 0.001; overweight: R(2) = 0.45, P < 0.001; and obese: R(2) = 0.26, P = 0.024).
CONCLUSIONS
Maternal overweight and obesity before pregnancy are associated with increased OS in the offspring.
目的
孕前肥胖与后代在儿童期和成年期患肥胖症和糖尿病的风险更高有关。本研究的目的是确定孕前母亲超重或肥胖与新生儿氧化应激（OS）之间的关联。
方法
根据母亲的孕前体重指数（BMI）将72对母婴分为以下几组：营养正常组（n = 21）、超重组（n = 32）和肥胖组（n = 19）。测量新生儿脐带血样本血浆中的丙二醛（MDA）和一氧化氮（NO）。
结果
新生儿的MDA水平随母亲BMI的增加而升高（P = 0.001），NO水平也如此（P = 0.019）。三组中每组的MDA和NO水平之间均存在直接相关性（营养正常组：R² = 0.
Zotero 插件