一种用于光触发药物释放和活细胞成像的发光钌（II）配合物。
A luminescent ruthenium(II) complex for light-triggered drug release and live cell imaging.
作者信息
Karaoun Nora, Renfrew Anna K
机构信息
School of Chemistry, University of Sydney, Sydney, Australia.
出版信息
Chem Commun (Camb). 2015 Sep 25;51(74):14038-41. doi: 10.1039/c5cc05172j.
PMID:26248575
Abstract
We report a novel ruthenium(II) complex for selective release of the imidazole-based drug econazole. While the complex is highly stable and luminescent in the dark, irradiation with green light induces release of one of the econazole ligands, which is accompanied by a turn-off luminescence response and up to a 34-fold increase in cytotoxicity towards tumour cells.
摘要
我们报道了一种用于选择性释放基于咪唑的药物益康唑的新型钌（II）配合物。该配合物在黑暗中高度稳定且有发光现象，而用绿光照射会诱导其中一个益康唑配体的释放，这伴随着发光响应的猝灭以及对肿瘤细胞的细胞毒性增加高达34倍。
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