The Role of Multidrug Resistance Efflux Pumps in Cancer: Revisiting a JNCI Publication Exploring Expression of the MDR1 (P-glycoprotein) Gene.
作者信息
Gottesman Michael M, Pastan Ira H
机构信息
Laboratory of Cell Biology (MMG) and Laboratory of Molecular Biology (IHP), Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
出版信息
J Natl Cancer Inst. 2015 Aug 18;107(9). doi: 10.1093/jnci/djv222. Print 2015 Sep.
Abstract
摘要
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2
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Mol Pharm. 2014 Oct 6;11(10):3452-62. doi: 10.1021/mp500230b. Epub 2014 Aug 22.
3
Multidrug resistance in relapsed acute myeloid leukemia: evidence of biological heterogeneity.
Cancer. 2013 Aug 15;119(16):3076-83. doi: 10.1002/cncr.28098. Epub 2013 May 14.
4
The clinical relevance of cancer cell lines.
J Natl Cancer Inst. 2013 Apr 3;105(7):452-8. doi: 10.1093/jnci/djt007. Epub 2013 Feb 21.
5
Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.
Clin Cancer Res. 2012 Jun 1;18(11):3197-206. doi: 10.1158/1078-0432.CCR-12-0056. Epub 2012 Apr 5.
6
Collateral sensitivity as a strategy against cancer multidrug resistance.
Drug Resist Updat. 2012 Feb-Apr;15(1-2):98-105. doi: 10.1016/j.drup.2012.03.002. Epub 2012 Apr 6.
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Drug resistance in the mouse cancer clinic.
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9
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