人泪液和睑脂脂质组的个体间及日间变异性：一项初步研究。
Intersubject and Interday Variability in Human Tear and Meibum Lipidomes: A Pilot Study.
作者信息
Brown Simon H J, Kunnen Carolina M E, Papas Eric B, Lazon de la Jara Percy, Willcox Mark D P, Blanksby Stephen J, Mitchell Todd W
机构信息
Illawarra Health and Medical Research Institute and School of Medicine, University of Wollongong, Wollongong, NSW, Australia.
Vision CRC, Sydney, NSW, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia; Brien Holden Vision Institute, Sydney, NSW, Australia.
出版信息
Ocul Surf. 2016 Jan;14(1):43-8. doi: 10.1016/j.jtos.2015.08.005. Epub 2015 Sep 28.
PURPOSE
Our aim was to quantitate day-to-day changes in the tear and meibum lipid profile of individual subjects in a pilot study of healthy humans.
METHODS
Matched tear and meibum samples were obtained from four subjects on three consecutive days. Quantitative lipid profiles of human basal tears and meibum were compared using multivariate analysis by principal components.
RESULTS
Substantial differences in the lipid profile between subjects were observed, while lipid profiles were steady across the three consecutive days of sampling. Multivariate principal component analysis demonstrated that lysophosphatidylcholine was the largest variant lipid class between subjects in tears, while wax esters comprised the most variation between subjects in meibum secretions.
CONCLUSION
Interday variability is shown to be much smaller than interpatient variability, suggesting that tears and meibum subjects both have unique profiles in humans.
目的
在一项针对健康人的初步研究中，我们的目标是定量个体受试者泪液和睑板腺脂质成分的每日变化。
方法
在连续三天从四名受试者获取匹配的泪液和睑板腺样本。使用主成分多变量分析比较人基础泪液和睑板腺的定量脂质成分。
结果
观察到受试者之间脂质成分存在显著差异，而在连续三天的采样过程中脂质成分保持稳定。多变量主成分分析表明，溶血磷脂酰胆碱是泪液中受试者之间最大的可变脂质类别，而蜡酯是睑板腺分泌物中受试者之间变化最大的成分。
结论
日间变异性远小于患者间变异性，这表明泪液和睑板腺在人类中都有独特的成分。
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