一种用于铝离子和细胞成像应用的“开启型”荧光化学传感器。
A "turn-on" fluorescent chemosensor for aluminum ion and cell imaging application.
作者信息
Guo Ailing, Zhu Ruitao, Ren Yuehong, Dong Jinlong, Feng Liheng
机构信息
School of Chinese Materia Medica, Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, PR China.
Department of Chemistry, Taiyuan Normal University, Taiyuan 030031, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:530-4. doi: 10.1016/j.saa.2015.09.009. Epub 2015 Sep 25.
A simple and efficient fluorescent chemosensor for Al(3+) is reported in the paper. The chemosensor is obtained by dehydration reaction of 2-hydroxy-1-naphthaldehyde and 2-aminophenol. The chemosensor has high selectivity and sensitivity for Al(3+) and displays fluorescence "off-on" switch signal. The detection limit of the chemosensor for Al(3+) can reach 1.0×10(-7) M in DMSO/H2O (1:9, v/v) solution. The mass spectra and Job's plot analysis confirm the 1:1 stoichiometry between chemosensor and Al(3+). Potential utilization of the probe as an intracellular sensor of Al(3+) in human cancer (HiSa) cells is also examined by confocal fluorescence microscopy.
该论文报道了一种用于铝离子（Al(3+)）的简单高效荧光化学传感器。该化学传感器通过2-羟基-1-萘甲醛与2-氨基苯酚的脱水反应制得。该化学传感器对Al(3+)具有高选择性和高灵敏度，并显示荧光“关-开”切换信号。在二甲基亚砜/水（1:9，体积比）溶液中，该化学传感器对Al(3+)的检测限可达1.0×10(-7) M。质谱和Job曲线分析证实了化学传感器与Al(3+)之间的化学计量比为1:1。还通过共聚焦荧光显微镜研究了该探针作为人类癌细胞（HiSa）中Al(3+)细胞内传感器的潜在用途。
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