脯氨酸脱氢酶基因多态性与精神分裂症风险之间的关系。
Relationship between polymorphisms in the proline dehydrogenase gene and schizophrenia risk.
作者信息
Ghasemvand F, Omidinia E, Salehi Z, Rahmanzadeh S
机构信息
Enzyme Technology Lab., Genetics & Metabolism Research Group, Pasteur Institute of Iran, Tehran, Iran.
Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
出版信息
Genet Mol Res. 2015 Oct 2;14(4):11681-91. doi: 10.4238/2015.October.2.1.
Previous studies have suggested that an association exists between the proline dehydrogenase gene (PRODH) and increased schizophrenia risk. We examined the prevalence of the PRODH 757C/T (Arg185Trp), 1766A/G (Gly521Arg), and 1852G/A (intronic mutation) polymorphisms in 175 patients with schizophrenia and 185 control subjects. All subjects were of Iranian ancestry. The PRODH 757TT, 1852AA, and 1766GG genotypes were associated with an increased risk of schizophrenia (odds ratio = 1.38, 95% confidence interval: 0.88-2.16, P = 0.001, P = 0.001, respectively). The activity alleles in the PRODH genotype combinations were associated with an increased risk of schizophrenia (haplotype analysis, TAG genotype P = 0.007). Our findings support a major role for the PRODH 757TT, 1766GG, and 1852AA genotypes alone and in combination for schizophrenia susceptibility.
先前的研究表明，脯氨酸脱氢酶基因（PRODH）与精神分裂症风险增加之间存在关联。我们检测了175例精神分裂症患者和185例对照受试者中PRODH 757C/T（Arg185Trp）、1766A/G（Gly521Arg）和1852G/A（内含子突变）多态性的发生率。所有受试者均为伊朗血统。PRODH 757TT、1852AA和1766GG基因型与精神分裂症风险增加相关（优势比分别为1.38、95%置信区间：0.88 - 2.16、P = 0.001、P = 0.001）。PRODH基因型组合中的活性等位基因与精神分裂症风险增加相关（单倍型分析，TAG基因型P = 0.007）。我们的研究结果支持PRODH 757TT、1766GG和1852AA基因型单独及联合在精神分裂症易感性中起主要作用。
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