姜黄素和芹菜素——对抗阿尔茨海默病慢性神经炎症的新型且有前景的疗法。
Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer's disease.
作者信息
Venigalla Madhuri, Gyengesi Erika, Münch Gerald
机构信息
Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, NSW, Australia.
Department of Pharmacology, School of Medicine, University of Western Sydney, Campbelltown, NSW, Australia ; Molecular Medicine Research Group, University of Western Sydney, Penrith, NSW, Australia.
出版信息
Neural Regen Res. 2015 Aug;10(8):1181-5. doi: 10.4103/1673-5374.162686.
Alzheimer's disease is a progressive neurodegenerative disorder, characterized by deposition of amyloid beta, neurofibrillary tangles, astrogliosis and microgliosis, leading to neuronal dysfunction and loss in the brain. Current treatments for Alzheimer's disease primarily focus on enhancement of cholinergic transmission. However, these treatments are only symptomatic, and no disease-modifying drug is available for Alzheimer's disease patients. This review will provide an overview of the proven antioxidant, anti-inflammatory, anti-amyloidogenic, neuroprotective, and cognition-enhancing effects of curcumin and apigenin and discuss the potential of these compounds for Alzheimer's disease prevention and treatment. We suggest that these compounds might delay the onset of Alzheimer's disease or slow down its progression, and they should enter clinical trials as soon as possible.
阿尔茨海默病是一种进行性神经退行性疾病，其特征为β-淀粉样蛋白沉积、神经原纤维缠结、星形胶质细胞增生和小胶质细胞增生，导致大脑中的神经元功能障碍和丧失。目前针对阿尔茨海默病的治疗主要集中在增强胆碱能传递。然而，这些治疗仅为对症治疗，尚无用于阿尔茨海默病患者的疾病修饰药物。本综述将概述姜黄素和芹菜素已证实的抗氧化、抗炎、抗淀粉样蛋白生成、神经保护和认知增强作用，并讨论这些化合物在阿尔茨海默病预防和治疗方面的潜力。我们认为这些化合物可能会延迟阿尔茨海默病的发病或减缓其进展，应尽快进入临床试验。
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