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德国健康风险研究所(HRI)数据库的特征与外部效度。

Characteristics and external validity of the German Health Risk Institute (HRI) Database.

作者信息

Andersohn Frank, Walker Jochen

机构信息

Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Frank Andersohn Consulting & Research Services, Berlin, Germany.

出版信息

Pharmacoepidemiol Drug Saf. 2016 Jan;25(1):106-9. doi: 10.1002/pds.3895. Epub 2015 Nov 3.

Abstract

PURPOSE

The aim of this study was to describe characteristics and external validity of the German Health Risk Institute (HRI) Database.

METHODS

The HRI Database is an anonymized healthcare database with longitudinal data from approximately six Mio Germans. In addition to demographic information (gender, age, region of residence), data on persistence of insurants over time, hospitalization rates, mortality rates and drug prescription rates were extracted from the HRI database for 2013. Corresponding national reference data were obtained from official sources.

RESULTS

The proportion of men and women was similar in the HRI Database and Germany, but the database population was slightly younger (mean 40.4 vs 43.7 years). The proportion of insurants living in the eastern part of Germany was lower in the HRI Database (10.1% vs 19.7%). There was good accordance to German reference data with respect to hospitalization rates, overall mortality rate and prescription rates for the 20 most often reimbursed drug classes, with the overall burden of morbidity being slightly lower in the HRI database. From insurants insured on 1 January 2009 (N = 6.2 Mio), a total of 70.6% survived and remained continuously insured with the same statutory health insurance until 31 December 2013. This proportion increased to 77.5% if only insurants ≥40 years were considered.

CONCLUSIONS

There was good overall accordance of the HRI database and the German population in terms of measures of morbidity, mortality and drug usage. Persistence of insurants with the database over time was high, indicating suitability of the data source for longitudinal epidemiological analyses.

摘要

目的

本研究旨在描述德国健康风险研究所(HRI)数据库的特征和外部有效性。

方法

HRI数据库是一个匿名的医疗保健数据库,包含约600万德国人的纵向数据。除了人口统计学信息(性别、年龄、居住地区)外,还从HRI数据库中提取了2013年参保人员的持续参保时间、住院率、死亡率和药物处方率数据。相应的国家参考数据来自官方来源。

结果

HRI数据库中的男性和女性比例与德国总体情况相似,但数据库中的人群年龄稍小(平均年龄40.4岁对43.7岁)。HRI数据库中居住在德国东部的参保人员比例较低(10.1%对19.7%)。在住院率、总死亡率以及20种最常报销药物类别的处方率方面,与德国参考数据有良好的一致性,HRI数据库中的总体发病负担略低。对于2009年1月1日参保的人员(N = 620万),到2013年12月31日,共有70.6%的人存活并继续参加同一项法定医疗保险。如果仅考虑年龄≥40岁的参保人员,这一比例将增至77.5%。

结论

HRI数据库与德国人群在发病率、死亡率和药物使用量方面总体上具有良好的一致性。随着时间推移,参保人员在数据库中的留存率很高,表明该数据源适用于纵向流行病学分析。

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