DeFreitas Mariana R, Quint Leslie E, Watcharotone Kuanwong, Nan Bin, Ranella Michael J, Hider Joanna R, Liu Peter S, Williams David M, Eliason Jonathan L, Patel Himanshu J
Medical School, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
Department of Radiology, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109-5030, USA.
Int J Cardiovasc Imaging. 2016 Apr;32(4):647-53. doi: 10.1007/s10554-015-0807-7. Epub 2015 Nov 24.
Aortic aneurysms are a significant cause of mortality, and the presence of multiple aneurysms may affect treatment plans. The purpose of this study was to determine the frequency of abdominal aortic aneurysms (AAAs) in patients with thoracic aortic aneurysms (TAAs) and to establish whether patient specific factors, such as gender and comorbidities, influenced the frequency of AAAs, thereby indicating if and when abdominal aortic evaluation is justified. Electronic medical records were reviewed from 1000 patients with a computed tomography (CT) angiogram of the chest and abdomen and a clinical diagnosis of TAA from Cardiac Surgery clinic between 2008 and 2013. 538 patients with history of aortic intervention, dissection, rupture or trauma were excluded. The frequency of AAAs among the 462 remaining patients was established, and statistical analysis was used to elucidate differences in frequency based on age, gender, comorbidities, and TAA location. Overall, 104 of 462 (22.5 %) patients with a TAA also had an AAA. There were significant differences in the frequency of AAA based on TAA location, age, and comorbidities. The following comorbidities showed positive associations with AAA using logistic regression analysis: age ≥65 (P < 0.0001; OR 30.1; CI 7.14-126.61), smoking history (P < 0.0001; OR 4.1; 2.35-7.30), and hypertension (P = 0.024; OR 2.1; CI 1.11-4.16). Aneurysms in the proximal/mid descending (P < 0.0001; OR 4.96; CI 2.32-10.61) and diaphragm level (P < 0.0001; OR 38.4; CI 14.71-100.15) of the aorta also showed a positive association with AAAs when adjusted for age and gender. AAA screening in patients with TAA is a reasonable, evidence-based option regardless of the TAA location, with the strongest support in patients >age 55, with systemic hypertension, a smoking history and/or a TAA in the descending thoracic aorta.
主动脉瘤是导致死亡的重要原因,多个动脉瘤的存在可能会影响治疗方案。本研究的目的是确定胸主动脉瘤(TAA)患者腹主动脉瘤(AAA)的发生率,并确定患者的特定因素,如性别和合并症,是否会影响AAA的发生率,从而表明腹主动脉评估是否合理以及何时合理。回顾了2008年至2013年间心脏外科门诊1000例有胸部和腹部计算机断层扫描(CT)血管造影且临床诊断为TAA的患者的电子病历。排除538例有主动脉干预、夹层、破裂或创伤史的患者。确定了其余462例患者中AAA的发生率,并采用统计分析来阐明基于年龄、性别、合并症和TAA位置的发生率差异。总体而言,462例TAA患者中有104例(22.5%)同时患有AAA。基于TAA位置、年龄和合并症,AAA的发生率存在显著差异。使用逻辑回归分析,以下合并症与AAA呈正相关:年龄≥65岁(P<0.0001;OR 30.1;CI 7.14-126.61)、吸烟史(P<0.0001;OR 4.1;2.35-7.30)和高血压(P=0.024;OR 2.1;CI 1.11-4.16)。在调整年龄和性别后,主动脉近端/中降部(P<0.0001;OR 4.96;CI 2.32-10.61)和膈肌水平(P<0.0001;OR 38.4;CI 14.71-100.15)的动脉瘤也与AAA呈正相关。无论TAA位置如何,对TAA患者进行AAA筛查都是一种合理的、基于证据的选择,在年龄>55岁、患有系统性高血压、有吸烟史和/或胸降主动脉有TAA的患者中支持力度最强。