价值肯定预防应激引起的内皮损伤：原理研究证明。
Prevention of Stress-Provoked Endothelial Injury by Values Affirmation: a Proof of Principle Study.
机构信息
Department of Psychiatry, Columbia University, New York, NY, USA.
Department of Medicine, Columbia University, New York, NY, USA.
出版信息
Ann Behav Med. 2016 Jun;50(3):471-9. doi: 10.1007/s12160-015-9756-6.
BACKGROUND
Few studies have tested whether cellular processes directly associated with cardiovascular disease risk can be influenced by a psychological inoculation.
PURPOSE
This study investigated whether values affirmation, a psychological procedure designed to reduce stress and threat perception, would prevent endothelial injury to social evaluative threat (SET).
METHODS
Participants (N=32) were randomized to SET, SET with values affirmation, or Control. SET was induced with the Trier Social Stress Test, and participants performed values affirmation prior to SET induction. Using flow cytometry, endothelial injury was assessed by measuring circulating levels of endothelial cell-derived microparticles (EMPs) phenotypic for endothelial cell activation (CD62E+), apoptosis (CD31+) or both (CD51+).
RESULTS
Social threat caused expected increases in circulating EMPs phenotypic of endothelial cell injury, a response completely attenuated in those receiving values affirmation.
CONCLUSIONS
This study, as proof of principle due to small sample size, shows cellular level, cardiovascular disease-relevant effects of social stress and provides the first evidence of inoculation against such effects by a psychological procedure.
背景
很少有研究检验过与心血管疾病风险直接相关的细胞过程是否可以通过心理接种来影响。
目的
本研究旨在探讨价值肯定（一种旨在减轻压力和威胁感知的心理程序）是否可以预防社会评价威胁（SET）引起的内皮损伤。
方法
参与者（N=32）随机分为 SET 组、SET 加价值肯定组和对照组。SET 通过特里尔社会应激测试（Trier Social Stress Test）诱导，参与者在 SET 诱导前进行价值肯定。通过流式细胞术，通过测量循环中内皮细胞来源的微颗粒（EMP）的表型来评估内皮损伤，这些微颗粒表现为内皮细胞激活（CD62E+）、凋亡（CD31+）或两者兼有（CD51+）。
结果
社会威胁导致循环中内皮细胞损伤的 EMP 表型预期增加，而接受价值肯定的人则完全消除了这种反应。
结论
由于样本量小，本研究仅作为原理验证，显示了社会压力对细胞水平、心血管疾病的相关影响，并首次提供了通过心理程序预防这种影响的证据。
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