Dr. Lütfi Kirdar Training and Research Hospital Urology Clinic, Tecerdagi Cad. Yakutlar Sitesi G/11, Kartal, Istanbul, Turkey.
Urolithiasis. 2016 Aug;44(4):371-6. doi: 10.1007/s00240-015-0850-9. Epub 2015 Dec 11.
To determine the possible predictive value of certain acute phase reactants CRP and ESR as well as radiologic parameters on the degree of impaction in ureteral stones. A total of 80 adult patients with a single opaque proximal ureteral stone were evaluated. A non-contrast CT was performed in all cases and all possible radiologic predictive parameters calculated. Additionally, to outline the degree of impaction at the stone site, two serum acute phase reactants namely CRP and ESR levels were also assessed. Patients were divided into two groups as follows; Group 1 (n:42) patients with normal CRP levels and Group 2 (n:38) patients with elevated levels of CRP. The data obtained in the subgroups were first comparatively evaluated with radiological parameters and the possible correlation between CRP values and these parameters was well evaluated. While the serum CRP levels were normal in 42 cases, they were elevated in 38 cases. Evaluation of the data from CRP subgroups and radiologic parameters showed that elevated levels of serum CRP were closely related with mean values of ureteral wall thickness (UWT) as well as mean level of hydronephrosis with a statistically significant difference. Additionally, a correlation analysis between serum CRP levels and all other parameters mentioned above demonstrated a statistically significant correlation between UWT, degree of hydronephrosis and serum ESR values. Evaluation of serum CRP and ESR values could let us to predict the UWT, a parameter which is closely related with the degree of stone impaction.
为了确定 CRP 和 ESR 等急性期反应物以及影像学参数对输尿管结石嵌顿程度的可能预测价值,我们评估了 80 例单一近端输尿管不透光结石的成年患者。所有病例均行非增强 CT 检查,并计算了所有可能的影像学预测参数。此外,为了描绘结石部位的嵌顿程度,还评估了两种血清急性期反应物即 CRP 和 ESR 水平。患者分为两组:CRP 水平正常的第 1 组(n:42)和 CRP 水平升高的第 2 组(n:38)。首先将亚组中的数据与影像学参数进行比较评估,并很好地评估了 CRP 值与这些参数之间的可能相关性。虽然 42 例患者的血清 CRP 水平正常,但 38 例患者的 CRP 水平升高。CRP 亚组和影像学参数的数据评估表明,血清 CRP 水平升高与输尿管壁厚度(UWT)的平均值以及肾积水的平均水平密切相关,差异有统计学意义。此外,对血清 CRP 水平与上述所有参数之间的相关性分析表明,UWT、肾积水程度和血清 ESR 值之间存在统计学显著相关性。评估血清 CRP 和 ESR 值可使我们预测 UWT,该参数与结石嵌顿程度密切相关。