加拿大甲癣菌（Sigler）与甲真菌病：德国一种新的类似皮肤癣菌的霉菌

[Onychocola canadensis Sigler in onychomycosis : A new dermatophyte-like mould in Germany].

作者信息

Nenoff P, Schorlemmer B, Uhrlaß S, Baunacke A, Baunacke A, Friedrichs C, Iffländer J, Syhre E, Schneider A, Krüger C, Maier T

机构信息

Labor für medizinische Mikrobiologie, Mölbiser Hauptstraße 8, 04571, Rötha/OT Mölbis, Deutschland.

Institut für Medizinische Diagnostik Greifswald, Pappelallee 1, 17489, Greifswald, Deutschland.

出版信息

Hautarzt. 2016 Sep;67(9):739-49. doi: 10.1007/s00105-015-3755-1.

DOI:10.1007/s00105-015-3755-1

PMID:26758910

Abstract

Moulds or non-dermatophyte moulds (NDM) are being increasingly isolated as causative agent of onychomycoses. Known causes of a NDM-OM are Scopulariopsis brevicaulis, Fusarium, Aspergillus, Acremonium, Neoscytalidium dimidiatum, Arthrographis kalrae, and Chaetomium. In this article, 5 patients with suspected nail infection due to Onychocola canadensis are reported for the first time in Germany. Systemic antifungal agents are not considered to be effective in NDM onychomycosis. In individual cases, however, terbinafine seems to be effective in Onychocola canadensis infection of the nails. Treatment of choice represents, however, nontraumatic nail avulsion using 40 % urea ointment followed by antifungal nail lacquer with ciclopirox olamine or amorolfine.

摘要

霉菌或非皮肤癣菌性霉菌（NDM）越来越多地被分离出来作为甲癣的病原体。已知的NDM引起的甲癣病因有短帚霉、镰刀菌、曲霉菌、枝顶孢霉、双间新暗色柱节孢、卡尔氏节孢子菌和毛壳菌。本文首次报道了德国5例疑似由加拿大甲癣菌引起指甲感染的患者。全身抗真菌药物被认为对NDM甲癣无效。然而，在个别病例中，特比萘芬似乎对加拿大甲癣菌引起的指甲感染有效。然而，首选的治疗方法是使用40%尿素软膏进行非创伤性拔甲，随后使用含环吡酮胺或阿莫罗芬的抗真菌指甲油。