秘鲁野生鸟类中甲型流感病毒的遗传多样性
The Genetic Diversity of Influenza A Viruses in Wild Birds in Peru.
作者信息
Nelson Martha I, Pollett Simon, Ghersi Bruno, Silva Maria, Simons Mark P, Icochea Eliana, Gonzalez Armando E, Segovia Karen, Kasper Matthew R, Montgomery Joel M, Bausch Daniel G
机构信息
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, United States of America.
Virology and Emerging Infections Department, United States Naval Medical Research Unit No. 6, Callao, Peru.
出版信息
PLoS One. 2016 Jan 19;11(1):e0146059. doi: 10.1371/journal.pone.0146059. eCollection 2016.
Our understanding of the global ecology of avian influenza A viruses (AIVs) is impeded by historically low levels of viral surveillance in Latin America. Through sampling and whole-genome sequencing of 31 AIVs from wild birds in Peru, we identified 10 HA subtypes (H1-H4, H6-H7, H10-H13) and 8 NA subtypes (N1-N3, N5-N9). The majority of Peruvian AIVs were closely related to AIVs found in North America. However, unusual reassortants, including a H13 virus containing a PA segment related to extremely divergent Argentinian viruses, suggest that substantial AIV diversity circulates undetected throughout South America.
拉丁美洲历来对禽流感 A 病毒（AIVs）的监测水平较低，这阻碍了我们对全球禽流感 A 病毒生态学的了解。通过对秘鲁野生鸟类的 31 株禽流感 A 病毒进行采样和全基因组测序，我们鉴定出 10 种血凝素（HA）亚型（H1-H4、H6-H7、H10-H13）和 8 种神经氨酸酶（NA）亚型（N1-N3、N5-N9）。大多数秘鲁禽流感 A 病毒与在北美发现的禽流感 A 病毒密切相关。然而，一些不寻常的重配病毒，包括一种含有与阿根廷极端不同病毒相关的 PA 基因片段的 H13 病毒，表明南美洲存在大量未被检测到的禽流感 A 病毒多样性在传播。
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