非编码RNA在胃癌中的新作用：发病机制及临床意义
Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications.
作者信息
Xie Shan-Shan, Jin Juan, Xu Xiao, Zhuo Wei, Zhou Tian-Hua
机构信息
Shan-Shan Xie, Juan Jin, Xiao Xu, Wei Zhuo, Tian-Hua Zhou, Department of Cell Biology and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang Province, China.
出版信息
World J Gastroenterol. 2016 Jan 21;22(3):1213-23. doi: 10.3748/wjg.v22.i3.1213.
Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs (ncRNAs) with cancer has been widely studied during the past decade. In general, ncRNAs have been classified as small ncRNAs, including microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). Emerging evidence shows that miRNAs and lncRNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of miRNAs and lncRNAs in gastric cancer. miRNAs and lncRNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing miRNAs and lncRNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of ncRNAs in gastric cancer development and their possible clinical significance.
胃癌是癌症相关死亡的主要原因。然而，胃癌发生的潜在机制在很大程度上仍不清楚。在过去十年中，非编码RNA（ncRNAs）与癌症的关联已得到广泛研究。一般来说，ncRNAs已被分类为小ncRNAs，包括微小RNA（miRNAs）和长链非编码RNA（lncRNAs）。新出现的证据表明，miRNAs和lncRNAs在许多癌症的形成和进展中起关键作用。在本综述中，我们聚焦于miRNAs和lncRNAs在胃癌中的调控作用。miRNAs和lncRNAs似乎通过多种机制参与胃癌肿瘤生长、侵袭和转移以及胃癌肿瘤微环境的建立。此外，我们还讨论了将miRNAs和lncRNAs确立为胃癌潜在生物标志物和治疗靶点的可能性。综上所述，我们总结了ncRNAs在胃癌发展中的新作用及其可能的临床意义。
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