晚期糖基化终产物在囊性纤维化相关糖尿病中升高，且与较差的肺功能相关。
Advanced glycation end products are elevated in cystic fibrosis-related diabetes and correlate with worse lung function.
作者信息
Hunt William R, Helfman Beth R, McCarty Nael A, Hansen Jason M
机构信息
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA; Emory+Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
Department of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Emory University, Atlanta, GA, USA; Emory+Children's Center for Cystic Fibrosis and Airways Disease Research, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
出版信息
J Cyst Fibros. 2016 Sep;15(5):681-8. doi: 10.1016/j.jcf.2015.12.011. Epub 2016 Jan 23.
BACKGROUND
The onset of cystic fibrosis-related diabetes (CFRD) exacerbates lung function decline and increases mortality. One pathway that may worsen the lung dysfunction associated with CFRD is that of the receptor for advanced glycation end products (RAGE) and its ligands.
METHODS
Human plasma was obtained from age-matched healthy, CF and CFRD patients. Plasma RAGE ligands (i.e. advanced glycation end products, S100A12, and high-mobility group protein B1) and soluble RAGE (sRAGE) levels were measured.
RESULTS
CFRD patients had elevated plasma levels of AGEs and S100A12. Soluble RAGE, a RAGE ligand decoy receptor, was not significantly different between groups. Plasma AGE levels and S100A12 levels had significantly negative correlations with FEV1.
CONCLUSIONS
AGEs are significantly elevated in CFRD and correlate negatively with FEV1. CFRD patients did not have significant increases in the decoy sRAGE, suggesting there may be heightened binding and activation of RAGE in CFRD exacerbating activation of proinflammatory pathways.
背景
囊性纤维化相关糖尿病（CFRD）的发病会加剧肺功能下降并增加死亡率。晚期糖基化终产物受体（RAGE）及其配体的途径可能是使与CFRD相关的肺功能障碍恶化的一个原因。
方法
从年龄匹配的健康、CF和CFRD患者中获取人血浆。测量血浆RAGE配体（即晚期糖基化终产物、S100A12和高迁移率族蛋白B1）和可溶性RAGE（sRAGE）水平。
结果
CFRD患者的血浆AGEs和S100A12水平升高。可溶性RAGE是一种RAGE配体诱饵受体，各组之间无显著差异。血浆AGE水平和S100A12水平与第一秒用力呼气容积（FEV1）呈显著负相关。
结论
CFRD患者的AGEs显著升高且与FEV1呈负相关。CFRD患者的诱饵sRAGE没有显著增加，这表明CFRD中RAGE的结合和激活可能增强，从而加剧促炎途径的激活。
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