一种基于二酮吡咯并吡咯的差异选择性探针，对Fe(3+)具有荧光开启响应，对Au(3+)具有双模式开启和比率响应及其在活细胞成像中的应用。
A differentially selective probe based on diketopyrrolopyrrole with fluorescence turn-on response to Fe(3+), and dual-mode turn-on and ratiometric response to Au(3+), and its application in living cell imaging.
作者信息
Yang Xiaofeng, Liu Xiaolei, Li Yexin, Wu Fan, Mao Jiaxin, Yuan Yuan, Cui Yu, Sun Guoxin, Zhang Guangyou
机构信息
School of Chemistry and Chemical Engineering, University of Jinan, No. 336, West Road of Nan Xinzhuang, Jinan 250022, Shandong, China; Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, University of Jinan, No. 336, West Road of Nan Xinzhuang, Jinan 250022, Shandong, China.
School of Chemistry and Chemical Engineering, University of Jinan, No. 336, West Road of Nan Xinzhuang, Jinan 250022, Shandong, China.
出版信息
Biosens Bioelectron. 2016 Jun 15;80:288-293. doi: 10.1016/j.bios.2016.01.085. Epub 2016 Feb 1.
A diketopyrrolopyrrole-based probe DPP-PyR was able to recognize Fe(3+) and Au(3+) with fluorescent turn-on response via different emission modes with relatively low detection limit. Moreover, DPP-PyR exhibited preferential second mode of selectivity for Au(3+) as it ratiometrically displaced Fe(3+) from the [DPP-PyR+Fe(3+)] complex. Furthermore, the imaging experiments indicated that this probe was cell-permeable and could be used to detect Fe(3+) and Au(3+) ions within living cell. To the best of our knowledge, it was the first probe for detection Fe(3+) and Au (3+) at the same time ever reported.
一种基于二酮吡咯并吡咯的探针DPP-PyR能够通过不同的发射模式以荧光开启响应识别Fe(3+)和Au(3+)，检测限相对较低。此外，DPP-PyR对Au(3+)表现出优先的第二种选择性模式，因为它以比率方式将Fe(3+)从[DPP-PyR+Fe(3+)]络合物中置换出来。此外，成像实验表明该探针具有细胞渗透性，可用于检测活细胞内的Fe(3+)和Au(3+)离子。据我们所知，这是有史以来报道的第一个同时检测Fe(3+)和Au(3+)的探针。
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