肝和胰腺再生中的干细胞与可塑性。
Stem cells versus plasticity in liver and pancreas regeneration.
机构信息
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada.
Oregon Stem Cell Center, Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon 97239, USA.
出版信息
Nat Cell Biol. 2016 Mar;18(3):238-45. doi: 10.1038/ncb3309.
Cell replacement in adult organs can be achieved through stem cell differentiation or the replication or transdifferentiation of existing cells. In the adult liver and pancreas, stem cells have been proposed to replace tissue cells, particularly following injury. Here we review how specialized cell types are produced in the adult liver and pancreas. Based on current evidence, we propose that the plasticity of differentiated cells, rather than stem cells, accounts for tissue repair in both organs.
成人器官中的细胞替代可以通过干细胞分化或现有细胞的复制或转分化来实现。在成年的肝脏和胰腺中，干细胞被提议用于替代组织细胞，特别是在损伤后。在这里，我们回顾了成人肝脏和胰腺中特化细胞类型的产生方式。基于目前的证据，我们提出，分化细胞的可塑性，而不是干细胞，解释了这两个器官中的组织修复。
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