中医药在疼痛治疗与调节方面的潜力。
The Potential of Traditional Chinese Medicine in the Treatment and Modulation of Pain.
作者信息
Du Guan-Hua, Yuan Tian-Yi, Du Li-da, Zhang Yong-Xiang
机构信息
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
State Key Laboratory of Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China; Beijing Key Laboratory of Drug Targets Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
出版信息
Adv Pharmacol. 2016;75:325-61. doi: 10.1016/bs.apha.2016.01.001. Epub 2016 Feb 9.
Pain is an unpleasant sensory and emotional experience associated with various diseases. Extensive research has been conducted to find appropriate methods of relieving pain and improving the quality of life. However, the most commonly used pain-relieving agents such as opioid therapeutics are often associated with harmful side effects; moreover, users are prone to become addicted to these agents and may develop tolerance. Often, nonopioid therapeutics is only marginally effective, thus leading to a significant unmet medical need. Scientists have studied herbal medicines, finding more than 800 kinds of traditional Chinese medicine (TCM) to be effective in relieving pain while also creating several monomeric compounds to develop novel analgesic drugs. In this review, we summarize the representative TCM currently available for the treatment and modulation of pain. Ten different natural products, mainly herbs, used in Chinese medicine to relieve pain are discussed in light of the theories of TCM and modern pharmacology. We hope that this review will provide valuable information for future studies on the potential of TCM in alleviating pain.
疼痛是一种与多种疾病相关的不愉快的感觉和情感体验。人们已经进行了广泛的研究，以寻找缓解疼痛和改善生活质量的合适方法。然而，最常用的止痛剂，如阿片类药物，往往会产生有害的副作用；此外，使用者容易对这些药物上瘾，并可能产生耐受性。通常，非阿片类药物的效果甚微，因此导致了巨大的未满足医疗需求。科学家们对草药进行了研究，发现800多种中药对缓解疼痛有效，同时还合成了几种单体化合物来开发新型镇痛药。在这篇综述中，我们总结了目前可用于治疗和调节疼痛的代表性中药。根据中医理论和现代药理学，讨论了十种主要用于中药止痛的不同天然产物，主要是草药。我们希望这篇综述能为未来关于中药缓解疼痛潜力的研究提供有价值的信息。
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