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[结痂性疥疮:综述]

[Crusted scabies: A review].

作者信息

Jouret G, Bounemeur R, Presle A, Takin R

机构信息

Service de dermatologie, centre hospitalier de Troyes, 101, avenue Anatole-France, 10000 Troyes, France.

Service d'accueil des urgences, centre hospitalier de Troyes, 101, avenue Anatole-France, 10000 Troyes, France.

出版信息

Ann Dermatol Venereol. 2016 Apr;143(4):251-6. doi: 10.1016/j.annder.2016.02.001. Epub 2016 Mar 2.

Abstract

Crusted scabies is a rare and severe form of infestation by Sarcoptes scabies var. hominis. It is characterized by profuse hyperkeratosis containing over 4000 mites per gram of skin, with treatment being long and difficult. The condition is both direct and indirectly contagious. It has a central role in epidemic cycles of scabies, the incidence of which is on the rise in economically stable countries. Recent discoveries concerning the biology of mites, the pathophysiology of hyperkeratosis and the key role of IL-17 in this severe form open up new therapeutic perspectives.

摘要

结痂性疥疮是由人疥螨引起的一种罕见且严重的感染形式。其特征为大量角化过度,每克皮肤中含有超过4000只螨虫,治疗过程漫长且困难。这种疾病具有直接和间接传染性。它在疥疮的流行周期中起核心作用,在经济稳定的国家,疥疮的发病率正在上升。最近关于螨虫生物学、角化过度的病理生理学以及白细胞介素-17在这种严重形式中所起关键作用的发现,为治疗开辟了新的前景。

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