纤毛发生的力学生物学
Mechanobiology of Ciliogenesis.
作者信息
Ishikawa Hiroaki, Marshall Wallace F
机构信息
Hiroaki Ishikawa and Wallace F. Marshall are affiliated with the Department of Biochemistry and Biophysics at the University of California San Francisco
出版信息
Bioscience. 2014 Dec 1;64(12):1084-1091. doi: 10.1093/biosci/biu173. Epub 2014 Nov 25.
Abstract
Cilia are force-generating and -sensing organelles that serve as mechanical interfaces between the cell and the extracellular environment. Cilia are present in tissues that adaptively respond to mechanical loading and fluid flow, and defects in ciliary function can lead to diseases affecting these tissues. As might be expected for a mechanical interface, the formation of cilia is, itself, regulated by mechanical forces, and these links between mechanics and ciliary formation are providing new entry points for dissecting the regulatory pathways of ciliogenesis.
摘要
纤毛是产生力和感知力的细胞器，作为细胞与细胞外环境之间的机械界面。纤毛存在于对机械负荷和流体流动产生适应性反应的组织中，纤毛功能缺陷可导致影响这些组织的疾病。正如对机械界面的预期那样，纤毛的形成本身受机械力调节，而力学与纤毛形成之间的这些联系为剖析纤毛发生的调控途径提供了新的切入点。
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