儿童HIV感染：治愈的可能性。
Paediatric HIV infection: the potential for cure.
作者信息
Goulder Philip J, Lewin Sharon R, Leitman Ellen M
机构信息
Department of Paediatrics, University of Oxford, Oxford OX1 3SY, UK.
The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne 3000, Australia.
出版信息
Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.
Abstract
Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.
摘要
最近有一些轶事报道称，感染艾滋病毒的儿童接受了早期抗逆转录病毒疗法（ART），即使在停止抗逆转录病毒疗法后仍能持续控制病毒复制，这引发了一个问题：与成人感染相比，儿童感染中艾滋病毒缓解甚至根除（“治愈”）的内在潜力是否更大。本综述描述了早期开始抗逆转录病毒疗法、免疫个体发育和母体因素对儿童艾滋病毒治愈潜力的影响，并讨论了儿童感染可能带来的独特免疫治疗机会和障碍。
相似文献
1
Paediatric HIV infection: the potential for cure.
Nat Rev Immunol. 2016 Apr;16(4):259-71. doi: 10.1038/nri.2016.19. Epub 2016 Mar 14.
2
Anti-retroviral therapy failure in HIV-1 infected pregnant women and its associated risk of HIV transmission.
Arch Gynecol Obstet. 2020 Nov;302(5):1229-1235. doi: 10.1007/s00404-020-05743-8. Epub 2020 Aug 14.
3
4
Antiretroviral therapy (ART) for treating HIV infection in ART-eligible pregnant women.
Cochrane Database Syst Rev. 2010 Mar 17(3):CD008440. doi: 10.1002/14651858.CD008440.
5
Maternal and infant factors and lymphocyte, CD4 and CD8 cell counts in uninfected children of HIV-1-infected mothers.
AIDS. 2005 Jul 1;19(10):1071-9. doi: 10.1097/01.aids.0000174454.63250.22.
6
British HIV Association guidelines for the management of HIV infection in pregnant women 2012 (2014 interim review).
HIV Med. 2014 Sep;15 Suppl 4:1-77. doi: 10.1111/hiv.12185.
7
The effect of prenatal highly active antiretroviral therapy on the transmission of congenital and perinatal/early postnatal cytomegalovirus among HIV-infected and HIV-exposed infants.
Clin Infect Dis. 2012 Sep;55(6):877-84. doi: 10.1093/cid/cis535. Epub 2012 Jun 6.
8
Successful prevention of HIV mother-to-child transmission with dolutegravir-based combination antiretroviral therapy in a vertically infected pregnant woman with multiclass highly drug-resistant HIV-1.
AIDS. 2015 Nov 28;29(18):2534-7. doi: 10.1097/QAD.0000000000000888.
9
Prevention of perinatal HIV transmission during pregnancy.
J Antimicrob Chemother. 2000 Nov;46(5):657-68. doi: 10.1093/jac/46.5.657.
10
Unexpected vertical transmission of HIV infection.
Eur J Pediatr. 2014 Jan;173(1):121-3. doi: 10.1007/s00431-013-2020-9. Epub 2013 May 8.
引用本文的文献
1
Impact of Delayed Early Antiretroviral Therapy Initiation on Treatment Outcomes in Infant Macaques Exposed to SHIVAD8.
Viruses. 2025 Jun 14;17(6):849. doi: 10.3390/v17060849.
2
The Complex Role of CD8+ T Cells in Placental HIV Infection.
Eur J Immunol. 2025 Jun;55(6):e51615. doi: 10.1002/eji.202451615.
3
Intact HIV DNA decays in children with and without complete viral load suppression.
PLoS Pathog. 2025 Apr 4;21(4):e1013003. doi: 10.1371/journal.ppat.1013003. eCollection 2025 Apr.
4
Autovaccination revisited: potential to boost antiviral immunity and facilitate HIV-1 cure/remission in children.
Curr Opin HIV AIDS. 2025 May 1;20(3):271-278. doi: 10.1097/COH.0000000000000924. Epub 2025 Mar 19.
5
Divergent populations of HIV-infected naive and memory CD4+ T cell clones in children on antiretroviral therapy.
J Clin Invest. 2025 Mar 6;135(9). doi: 10.1172/JCI188533. eCollection 2025 May 1.
6
Human models that inform antiretroviral therapy-free remission with perinatally acquired HIV infection.
Curr Opin HIV AIDS. 2025 May 1;20(3):249-256. doi: 10.1097/COH.0000000000000918. Epub 2025 Mar 19.
7
Long-term non-progression in children with HIV: estimates from international cohort data.
AIDS. 2025 May 1;39(6):746-759. doi: 10.1097/QAD.0000000000004136. Epub 2025 Feb 4.
8
Interventions during Early Infection: Opening a Window for an HIV Cure?
Viruses. 2024 Oct 9;16(10):1588. doi: 10.3390/v16101588.
9
Assessing the impact of autologous virus neutralizing antibodies on viral rebound time in postnatally SHIV-infected ART-treated infant rhesus macaques.
Epidemics. 2024 Sep;48:100780. doi: 10.1016/j.epidem.2024.100780. Epub 2024 Jun 27.
10
Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission.
Nat Med. 2024 Oct;30(10):2796-2804. doi: 10.1038/s41591-024-03105-4. Epub 2024 Jun 6.
本文引用的文献
1
HIV-1 virological remission lasting more than 12 years after interruption of early antiretroviral therapy in a perinatally infected teenager enrolled in the French ANRS EPF-CO10 paediatric cohort: a case report.
Lancet HIV. 2016 Jan;3(1):e49-54. doi: 10.1016/S2352-3018(15)00232-5. Epub 2015 Dec 9.
2
Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
Lancet HIV. 2015 Dec;2(12):e520-9. doi: 10.1016/S2352-3018(15)00226-X. Epub 2015 Nov 17.
3
Blood-Derived CD4 T Cells Naturally Resist Pyroptosis during Abortive HIV-1 Infection.
Cell Host Microbe. 2015 Oct 14;18(4):463-70. doi: 10.1016/j.chom.2015.09.010.
4
Immunological biomarkers predict HIV-1 viral rebound after treatment interruption.
Nat Commun. 2015 Oct 9;6:8495. doi: 10.1038/ncomms9495.
5
Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial.
Lancet HIV. 2014 Oct;1(1):e13-21. doi: 10.1016/S2352-3018(14)70014-1. Epub 2014 Sep 15.
6
Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection.
PLoS Pathog. 2015 Sep 24;11(9):e1005153. doi: 10.1371/journal.ppat.1005153. eCollection 2015 Sep.
7
The Depsipeptide Romidepsin Reverses HIV-1 Latency In Vivo.
PLoS Pathog. 2015 Sep 17;11(9):e1005142. doi: 10.1371/journal.ppat.1005142. eCollection 2015 Sep.
8
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point.
Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8.
9
CNS-specific regulatory elements in brain-derived HIV-1 strains affect responses to latency-reversing agents with implications for cure strategies.
Mol Psychiatry. 2016 Apr;21(4):574-84. doi: 10.1038/mp.2015.111. Epub 2015 Aug 25.
10
Cell-Associated HIV-1 DNA and RNA Decay Dynamics During Early Combination Antiretroviral Therapy in HIV-1-Infected Infants.
Clin Infect Dis. 2015 Dec 15;61(12):1862-70. doi: 10.1093/cid/civ688. Epub 2015 Aug 13.
Zotero 插件