采用 SHROB 大鼠模型分析不同 EPA:DHA 比例饮食对代谢综合征进展的影响的脂质组学研究。

Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model.

机构信息

Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain; Department of Analytical Chemistry, Nutrition and Bromatology and Research Institute for Food Analysis (I.I.A.A.), University of Santiago de Compostela, E-15782 Santiago de Compostela, Galicia, Spain.

Instituto de Investigaciones Marinas, Consejo Superior de Investigaciones Científicas (IIM-CSIC), E-36208 Vigo, Galicia, Spain.

出版信息

Food Chem. 2016 Aug 15;205:196-203. doi: 10.1016/j.foodchem.2016.03.020. Epub 2016 Mar 8.

DOI:10.1016/j.foodchem.2016.03.020

PMID:27006231

Abstract

The role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS.

摘要

本研究旨在探讨ω-3 EPA 和 DHA 的特定比例在调节与代谢综合征进展相关的炎症和氧化应激标志物中的作用。在代谢紊乱动物模型中，我们将潜在的炎症类二十烷酸和二十二碳六烯酸与心血管疾病、肥胖、炎症和氧化应激的生物标志物一起讨论。结果表明，1:1 和 2:1 EPA:DHA 比例的饮食比 1:2 EPA:DHA 饮食具有更好的健康效果，其通过下调强促炎ω-6 类二十烷酸的产生、降低氧化应激标志物、调节脂肪酸去饱和酶活性以及增加血浆和膜多不饱和脂肪酸（PUFAs）来实现抗炎特性。这些结果有助于增加人们对海洋脂质健康益处的了解，并为研究其在代谢综合征、炎症和氧化应激进展中的作用提供理论依据。此外，本研究结果还阐明了 EPA 和 DHA 的保护机制，为设计旨在降低代谢综合征的饮食干预措施提供了新的思路。