联合癌症治疗与免疫检查点阻断：干扰素信号的汇聚。
Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling.
机构信息
Department of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Cell. 2016 Apr 7;165(2):272-5. doi: 10.1016/j.cell.2016.03.031.
Improving efficacy of immune checkpoint blockade for cancer can be facilitated by combining these agents with each other and/or with other conventional or targeted therapies. Interferon and innate immune signaling pathways in immune and tumor cells have emerged as intriguing determinants of response and resistance, often in complex and seemingly paradoxical ways.
为了提高癌症免疫检查点阻断的疗效，可以将这些药物联合使用，或与其他常规或靶向治疗联合使用。免疫细胞和肿瘤细胞中的干扰素和固有免疫信号通路已成为反应和耐药的有趣决定因素，其作用方式往往复杂且似乎相互矛盾。
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