TMEM132D区域的多态性与日本人群中HLA-DRB1*13:02阴性个体的惊恐障碍相关。
Polymorphisms in the TMEM132D region are associated with panic disorder in HLA-DRB1*13:02-negative individuals of a Japanese population.
作者信息
Shimada-Sugimoto Mihoko, Otowa Takeshi, Miyagawa Taku, Khor Seik-Soon, Omae Yosuke, Toyo-Oka Licht, Sugaya Nagisa, Kawamura Yoshiya, Umekage Tadashi, Miyashita Akinori, Kuwano Ryozo, Kaiya Hisanobu, Kasai Kiyoto, Tanii Hisashi, Okazaki Yuji, Tokunaga Katsushi, Sasaki Tsukasa
机构信息
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo , Tokyo, Japan.
Graduate School of Clinical Psychology, Teikyo Heisei University Major of Professional Clinical Psychology , Tokyo, Japan.
出版信息
Hum Genome Var. 2016 Feb 25;3:16001. doi: 10.1038/hgv.2016.1. eCollection 2016.
We herein report an association between TMEM132D and panic disorder (PD) in a Japanese population, evaluating the effects of HLA-DRB113:02, which we previously reported as a susceptibility genetic factor for PD. SNPs in TMEM132D showed significant associations with PD in subjects without HLA-DRB113:02 (rs4759997; P=5.02×10(-6), odds ratio=1.50) but not in those with the HLA allele. TMEM132D might have a role in the development of PD in subjects without HLA-DRB1*13:02.
我们在此报告在日本人群中TMEM132D与惊恐障碍（PD）之间的关联，评估HLA - DRB113:02的影响，我们之前报道其为PD的一个易感基因因素。在没有HLA - DRB113:02的受试者中，TMEM132D中的单核苷酸多态性（SNP）与PD显示出显著关联（rs4759997；P = 5.02×10⁻⁶，优势比 = 1.50），但在携带该HLA等位基因的受试者中则无此关联。TMEM132D可能在没有HLA - DRB1*13:02的受试者的PD发病过程中起作用。
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