通过全基因组分析确定的与主观幸福感、抑郁症状和神经质相关的基因变异。
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
作者信息
Okbay Aysu, Baselmans Bart M L, De Neve Jan-Emmanuel, Turley Patrick, Nivard Michel G, Fontana Mark Alan, Meddens S Fleur W, Linnér Richard Karlsson, Rietveld Cornelius A, Derringer Jaime, Gratten Jacob, Lee James J, Liu Jimmy Z, de Vlaming Ronald, Ahluwalia Tarunveer S, Buchwald Jadwiga, Cavadino Alana, Frazier-Wood Alexis C, Furlotte Nicholas A, Garfield Victoria, Geisel Marie Henrike, Gonzalez Juan R, Haitjema Saskia, Karlsson Robert, van der Laan Sander W, Ladwig Karl-Heinz, Lahti Jari, van der Lee Sven J, Lind Penelope A, Liu Tian, Matteson Lindsay, Mihailov Evelin, Miller Michael B, Minica Camelia C, Nolte Ilja M, Mook-Kanamori Dennis, van der Most Peter J, Oldmeadow Christopher, Qian Yong, Raitakari Olli, Rawal Rajesh, Realo Anu, Rueedi Rico, Schmidt Börge, Smith Albert V, Stergiakouli Evie, Tanaka Toshiko, Taylor Kent, Thorleifsson Gudmar, Wedenoja Juho, Wellmann Juergen, Westra Harm-Jan, Willems Sara M, Zhao Wei, Amin Najaf, Bakshi Andrew, Bergmann Sven, Bjornsdottir Gyda, Boyle Patricia A, Cherney Samantha, Cox Simon R, Davies Gail, Davis Oliver S P, Ding Jun, Direk Nese, Eibich Peter, Emeny Rebecca T, Fatemifar Ghazaleh, Faul Jessica D, Ferrucci Luigi, Forstner Andreas J, Gieger Christian, Gupta Richa, Harris Tamara B, Harris Juliette M, Holliday Elizabeth G, Hottenga Jouke-Jan, De Jager Philip L, Kaakinen Marika A, Kajantie Eero, Karhunen Ville, Kolcic Ivana, Kumari Meena, Launer Lenore J, Franke Lude, Li-Gao Ruifang, Liewald David C, Koini Marisa, Loukola Anu, Marques-Vidal Pedro, Montgomery Grant W, Mosing Miriam A, Paternoster Lavinia, Pattie Alison, Petrovic Katja E, Pulkki-Råback Laura, Quaye Lydia, Räikkönen Katri, Rudan Igor, Scott Rodney J, Smith Jennifer A, Sutin Angelina R, Trzaskowski Maciej, Vinkhuyzen Anna E, Yu Lei, Zabaneh Delilah, Attia John R, Bennett David A, Berger Klaus, Bertram Lars, Boomsma Dorret I, Snieder Harold, Chang Shun-Chiao, Cucca Francesco, Deary Ian J, van Duijn Cornelia M, Eriksson Johan G, Bültmann Ute, de Geus Eco J C, Groenen Patrick J F, Gudnason Vilmundur, Hansen Torben, Hartman Catharine A, Haworth Claire M A, Hayward Caroline, Heath Andrew C, Hinds David A, Hyppönen Elina, Iacono William G, Järvelin Marjo-Riitta, Jöckel Karl-Heinz, Kaprio Jaakko, Kardia Sharon L R, Keltikangas-Järvinen Liisa, Kraft Peter, Kubzansky Laura D, Lehtimäki Terho, Magnusson Patrik K E, Martin Nicholas G, McGue Matt, Metspalu Andres, Mills Melinda, de Mutsert Renée, Oldehinkel Albertine J, Pasterkamp Gerard, Pedersen Nancy L, Plomin Robert, Polasek Ozren, Power Christine, Rich Stephen S, Rosendaal Frits R, den Ruijter Hester M, Schlessinger David, Schmidt Helena, Svento Rauli, Schmidt Reinhold, Alizadeh Behrooz Z, Sørensen Thorkild I A, Spector Tim D, Starr John M, Stefansson Kari, Steptoe Andrew, Terracciano Antonio, Thorsteinsdottir Unnur, Thurik A Roy, Timpson Nicholas J, Tiemeier Henning, Uitterlinden André G, Vollenweider Peter, Wagner Gert G, Weir David R, Yang Jian, Conley Dalton C, Smith George Davey, Hofman Albert, Johannesson Magnus, Laibson David I, Medland Sarah E, Meyer Michelle N, Pickrell Joseph K, Esko Tõnu, Krueger Robert F, Beauchamp Jonathan P, Koellinger Philipp D, Benjamin Daniel J, Bartels Meike, Cesarini David
机构信息
Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
出版信息
Nat Genet. 2016 Jun;48(6):624-33. doi: 10.1038/ng.3552. Epub 2016 Apr 18.
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
很少有基因变异与抑郁症和神经质相关联，这可能是因为以往研究的样本量有限。主观幸福感是一种与这两种特质都存在遗传相关性的表型，但尚未使用全基因组数据进行研究。我们对三种表型进行了全基因组关联研究：主观幸福感（n = 298,420）、抑郁症状（n = 161,460）和神经质（n = 170,911）。我们鉴定出3个与主观幸福感相关的变异、2个与抑郁症状相关的变异以及11个与神经质相关的变异，其中包括2个倒位多态性。与抑郁症状相关的两个基因座在一个独立的抑郁症样本中得到了重复验证。利用这些表型之间的高度遗传相关性（|ρ^| ≈ 0.8）进行的联合分析增强了研究结果的整体可信度，并使我们能够识别出更多变异。在我们研究的所有表型中，在中枢神经系统以及肾上腺或胰腺组织中调控表达的基因座与关联的富集程度很高。
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