ABO血型在克罗恩病及英夫利昔单抗治疗反应监测中的作用。
The role of ABO blood groups in Crohn's disease and in monitoring response to infliximab treatment.
作者信息
Yu Qiao, Wang Lingyun, Zhang Shenghong, Feng Ting, Li Li, Chen Baili, Chen Minhu
机构信息
Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Blood Transfus. 2016 Sep;14(5):460-4. doi: 10.2450/2016.0199-15. Epub 2016 Feb 24.
BACKGROUND
The variation in ABO blood groups is reported to be associated with multiple diseases. Infliximab (IFX) has been widely used in the treatment of Crohn's disease (CD). We aim to investigate the distribution of ABO blood groups in Chinese patients with CD and to explore its impact on response to IFX.
MATERIALS AND METHODS
Patients with CD were consecutively recruited to the study between 2007 and 2014. CD patients receiving IFX therapy were followed for at least two years.
RESULTS
In 293 patients with CD, most patients (40.6%) had blood type O (119/293). The odds ratio (OR) of CD in blood type O patients was 1.06 (95%CI: 0.6-1.86; p=0.84) compared to all other blood types. Among those CD patients, 107 patients received IFX treatment. One year after the first course of IFX, a significant association was found between the overall ABO system and outcomes of IFX treatment (p<0.001). CD patients with blood type AB (OR=4.42, 95% CI: 1.04-18.76; p=0.044) were more likely to achieve mucosal healing, while CD patients with blood type A had a high risk of losing response (OR=0.38, 95% CI: 0.15-0.96; p=0.040).
DISCUSSION
ABO blood groups are not associated with prevalence of CD. Patients with blood type AB had a better response to IFX while those with blood type A appeared to have a risk of losing response to IFX.
背景
据报道，ABO血型的变异与多种疾病相关。英夫利昔单抗（IFX）已广泛用于治疗克罗恩病（CD）。我们旨在调查中国CD患者的ABO血型分布，并探讨其对IFX治疗反应的影响。
材料与方法
2007年至2014年期间连续招募CD患者进行研究。接受IFX治疗的CD患者随访至少两年。
结果
在293例CD患者中，大多数患者（40.6%）为O型血（119/293）。与所有其他血型相比，O型血患者患CD的比值比（OR）为1.06（95%CI：0.6 - 1.86；p = 0.84）。在这些CD患者中，107例接受了IFX治疗。IFX第一个疗程后一年，发现ABO血型系统总体与IFX治疗结果之间存在显著关联（p < 0.001）。AB型血的CD患者更有可能实现黏膜愈合（OR = 4.42，95%CI：1.04 - 18.76；p = 0.044），而A型血的CD患者失去反应的风险较高（OR = 0.38，95%CI：0.15 - 0.96；p = 0.040）。
讨论
ABO血型与CD的患病率无关。AB型血的患者对IFX反应较好，而A型血的患者似乎有失去对IFX反应的风险。
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