采用基于病毒的免疫疗法与小分子BH3模拟物相结合的前列腺癌新型疗法。
Novel therapy of prostate cancer employing a combination of viral-based immunotherapy and a small molecule BH3 mimetic.
作者信息
Sarkar Siddik, Pradhan Anjan, Das Swadesh K, Emdad Luni, Sarkar Devanand, Pellecchia Maurizio, Fisher Paul B
机构信息
Department of Human and Molecular Genetics, Virginia Commonwealth University , Richmond, VA, USA.
Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, USA; VCU Institute of Molecular Medicine, Virginia Commonwealth University, Richmond, VA, USA; VCU Massey Cancer Center, School of Medicine, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Oncoimmunology. 2015 Sep 4;5(3):e1078059. doi: 10.1080/2162402X.2015.1078059. eCollection 2016 Mar.
Abstract
Cancer-selective viral replication and delivery of a therapeutic immunomodulating, cancer-selective killing cytokine () by means of a new () combined with a small molecule BH3 mimetic holds promise for treating both primary and metastatic hormone refractory prostate cancer (CaP).
摘要
通过一种新型的[具体名称未给出]与一种小分子BH3模拟物相结合，实现癌症选择性病毒复制并递送一种治疗性免疫调节、癌症选择性杀伤细胞因子（[具体名称未给出]），这为治疗原发性和转移性激素难治性前列腺癌（CaP）带来了希望。
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