Enrichr：一个全面的基因集富集分析网络服务器2016年更新版。
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
作者信息
Kuleshov Maxim V, Jones Matthew R, Rouillard Andrew D, Fernandez Nicolas F, Duan Qiaonan, Wang Zichen, Koplev Simon, Jenkins Sherry L, Jagodnik Kathleen M, Lachmann Alexander, McDermott Michael G, Monteiro Caroline D, Gundersen Gregory W, Ma'ayan Avi
机构信息
Department of Pharmacology and Systems Therapeutics, BD2K-LINCS Data Coordination and Integration Center, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place Box 1215, New York, NY 10029, USA.
Fluid Physics and Transport Processes Branch, NASA Glenn Research Center, 21000 Brookpark Rd., Cleveland, OH 44135, USA.
出版信息
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7. doi: 10.1093/nar/gkw377. Epub 2016 May 3.
Enrichment analysis is a popular method for analyzing gene sets generated by genome-wide experiments. Here we present a significant update to one of the tools in this domain called Enrichr. Enrichr currently contains a large collection of diverse gene set libraries available for analysis and download. In total, Enrichr currently contains 180 184 annotated gene sets from 102 gene set libraries. New features have been added to Enrichr including the ability to submit fuzzy sets, upload BED files, improved application programming interface and visualization of the results as clustergrams. Overall, Enrichr is a comprehensive resource for curated gene sets and a search engine that accumulates biological knowledge for further biological discoveries. Enrichr is freely available at: http://amp.pharm.mssm.edu/Enrichr.
富集分析是一种用于分析全基因组实验产生的基因集的常用方法。在此，我们对该领域的一个名为Enrichr的工具进行了重大更新。Enrichr目前包含大量可供分析和下载的不同基因集文库。总体而言，Enrichr目前共有来自102个基因集文库的180184个注释基因集。Enrichr添加了新功能，包括提交模糊集的能力、上传BED文件、改进的应用程序编程接口以及将结果可视化为聚类图。总的来说，Enrichr是一个用于整理基因集的综合资源，也是一个积累生物学知识以促进进一步生物学发现的搜索引擎。可通过以下网址免费访问Enrichr：http://amp.pharm.mssm.edu/Enrichr。
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