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从经济学角度探讨膝关节和髋关节骨关节炎管理中的肥胖问题

Addressing obesity in the management of knee and hip osteoarthritis - weighing in from an economic perspective.

作者信息

Flego Anna, Dowsey Michelle M, Choong Peter F M, Moodie Marj

机构信息

Deakin Health Economics, Faculty of Health, Deakin University, 221 Burwood Hwy, Burwood, Melbourne, 3125, Australia.

Department of Surgery, University of Melbourne, St. Vincent's Hospital, Melbourne, VIC, Australia.

出版信息

BMC Musculoskelet Disord. 2016 May 26;17:233. doi: 10.1186/s12891-016-1087-7.

Abstract

BACKGROUND

Obesity is one of the only modifiable risk factors for both incidence and progression of Osteoarthritis (OA). So there is increasing interest from a public health perspective in addressing obesity in the management of OA. While evidence of the efficacy of intereventions designed to address obesity in OA populations continues to grow, little is known about their economic credentials. The aim of this study is to conduct a scoping review of: (i) the published economic evidence assessing the economic impact of obesity in OA populations; (ii) economic evaluations of interventions designed to explicitly address obesity in the prevention and management of OA in order to determine which represent value for money. Besides describing the current state of the literature, the study highlights research gaps and identifies future research priorities.

METHODS

In July 2014, a search of the peer reviewed literature, published in English, was undertaken for the period January 1975 - July 2014 using Medline Complete (Ebscohost), Embase, Econlit, Global Health, Health Economics Evaluation Database (HEED), all Cochrane Library databases as well as the grey literature using Google and reference lists of relevant studies. A combination of key search terms was used to identify papers assessing the economic impact of obesity in OA or economic evaluations conducted to assess the efficiency of obesity interventions for the prevention or management of OA.

RESULTS

14 studes were identified; 13 were cost burden studies assessing the impact of obesity as a predictor for higher costs in Total Joint Arthroplasty (TJA) patients and one a cost-effectiveness study of an intervention designed to address obesity in the managment of mild to moderate OA patients.

CONCLUSION

The majority of the economic studies conducted are cost burden studies. While there is some evidence of the association between severe obesity and excess hospital costs for TJA patients, heterogeneity in studies precludes definitive statements about the strength of the association. With only one economic evaluation to inform policy and practice, there is a need for future research into the cost-effectiveness of obesity interventions designed both for prevention or management of OA along the disease spectrum and over the life course.

摘要

背景

肥胖是骨关节炎(OA)发病和病情进展中少数可改变的风险因素之一。因此,从公共卫生角度来看,在OA管理中应对肥胖问题的关注度日益增加。虽然旨在解决OA人群肥胖问题的干预措施的疗效证据不断增加,但对其经济状况却知之甚少。本研究的目的是进行一项范围界定审查:(i)评估肥胖对OA人群经济影响的已发表经济证据;(ii)旨在明确解决肥胖问题以预防和管理OA的干预措施的经济评估,以确定哪些具有性价比。除了描述文献的现状外,该研究还突出了研究差距并确定了未来的研究重点。

方法

2014年7月,使用Medline Complete(Ebscohost)、Embase、Econlit、Global Health、健康经济学评估数据库(HEED)、所有Cochrane图书馆数据库以及通过谷歌搜索的灰色文献和相关研究的参考文献列表,对1975年1月至2014年7月期间以英文发表的同行评审文献进行了检索。使用一组关键搜索词来识别评估肥胖对OA经济影响的论文,或为评估肥胖干预措施预防或管理OA的效率而进行的经济评估。

结果

共识别出14项研究;13项是成本负担研究,评估肥胖作为全关节置换术(TJA)患者更高成本预测因素的影响,1项是针对轻度至中度OA患者管理中旨在解决肥胖问题的干预措施的成本效益研究。

结论

进行的大多数经济研究都是成本负担研究。虽然有一些证据表明严重肥胖与TJA患者的额外医院成本之间存在关联,但研究的异质性使得无法就该关联的强度做出明确陈述。由于只有一项经济评估为政策和实践提供参考,因此需要未来开展研究,以探讨针对OA预防或管理的肥胖干预措施在疾病谱和生命历程中的成本效益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/58bf/4882789/8888a81ac86a/12891_2016_1087_Fig1_HTML.jpg

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