疼痛与瘙痒：对抗感染防御有益还是有害？
Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?
机构信息
Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.
Department of Microbiology and Immunobiology, Division of Immunology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Host Microbe. 2016 Jun 8;19(6):755-9. doi: 10.1016/j.chom.2016.05.010.
Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.
疼痛和瘙痒是伴随许多微生物感染的不愉快感觉。最近的研究表明，疼痛和瘙痒介导的躯体感觉神经元能够直接检测病原体，触发神经元激活和随后的免疫反应调节。我们讨论感染期间的疼痛和/或瘙痒对宿主抗菌防御是有益还是有害。
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