Thillaivanam Saravanapriya, Amin Arwa M, Gopalakrishnan Sheila, Ibrahim Baharudin
Department of Pharmacy, Hospital Kulim, Kulim, Kedah, Malaysia.
Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Minden, Pulau Pinang, Malaysia.
Pediatr Res. 2016 Oct;80(4):516-20. doi: 10.1038/pr.2016.113. Epub 2016 May 24.
Sore throats may be due to either viral or group A beta hemolytic streptococcus (GABHS) infections; but diagnosis of the etiology of a sore throat is difficult, often leading to unnecessary antibiotic prescriptions and consequent increases in bacterial resistance. Scoring symptoms using the McIsaac clinical decision rule can help physicians to diagnose and manage streptococcal infections leading to sore throat and have been recommended by the Ministry of Health, Malaysia. In this paper, we offer the first assessment of the effectiveness of the McIsaac rule in a clinical setting in Malaysia.
This study is a retrospective review of 116 pediatric patients presenting with sore throat. Group A comprised patients before the implementation of the McIsaac rule and Group B comprised patients after the implementation.
Unnecessary throat swab cultures were reduced by 40% (P = 0.003). Redundant antibiotic prescriptions were reduced by 26.5% (P = 0.003) and the overall use of antibiotics was reduced by 22.1% (P = 0.003). The pediatricians' compliance rate to McIsaac rule criteria was 45% before implementation of the McIsaac rule, but improved to 67.9% (P = 0.0005) after implementation.
The McIsaac rule is an effective tool for the management of sore throat in children in Malaysia.
喉咙痛可能由病毒感染或 A 组β溶血性链球菌(GABHS)感染引起;但喉咙痛病因的诊断较为困难,常常导致不必要的抗生素处方,进而增加细菌耐药性。使用麦基萨克临床决策规则对症状进行评分有助于医生诊断和管理导致喉咙痛的链球菌感染,马来西亚卫生部已推荐该规则。在本文中,我们首次评估了麦基萨克规则在马来西亚临床环境中的有效性。
本研究是对 116 例出现喉咙痛的儿科患者的回顾性分析。A 组包括在麦基萨克规则实施前的患者,B 组包括在实施后的患者。
不必要的咽拭子培养减少了 40%(P = 0.003)。多余的抗生素处方减少了 26.5%(P = 0.003),抗生素的总体使用量减少了 22.1%(P = 0.003)。在麦基萨克规则实施前,儿科医生对麦基萨克规则标准的依从率为 45%,但实施后提高到了 67.9%(P = 0.0005)。
麦基萨克规则是马来西亚管理儿童喉咙痛的有效工具。