潜伏期逆转和病毒清除以治愈HIV-1。
Latency reversal and viral clearance to cure HIV-1.
作者信息
Margolis David M, Garcia J Victor, Hazuda Daria J, Haynes Barton F
机构信息
University of North Carolina HIV Cure Center, Department of Medicine, and Center for AIDS Research, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC, USA.
出版信息
Science. 2016 Jul 22;353(6297):aaf6517. doi: 10.1126/science.aaf6517.
Research toward a cure for human immunodeficiency virus type 1 (HIV-1) infection has joined prevention and treatment efforts in the global public health agenda. A major approach to HIV eradication envisions antiretroviral suppression, paired with targeted therapies to enforce the expression of viral antigen from quiescent HIV-1 genomes, and immunotherapies to clear latent infection. These strategies are targeted to lead to viral eradication--a cure for AIDS. Paired testing of latency reversal and clearance strategies has begun, but additional obstacles to HIV eradication may emerge. Nevertheless, there is reason for optimism that advances in long-acting antiretroviral therapy and HIV prevention strategies will contribute to efforts in HIV cure research and that the implementation of these efforts will synergize to markedly blunt the effect of the HIV pandemic on society.
针对人类免疫缺陷病毒1型（HIV-1）感染的治愈研究已成为全球公共卫生议程中预防和治疗工作的一部分。根除HIV的一种主要方法设想是进行抗逆转录病毒抑制，同时配合靶向疗法以促使潜伏的HIV-1基因组表达病毒抗原，并采用免疫疗法清除潜伏感染。这些策略旨在实现病毒根除——治愈艾滋病。潜伏逆转和清除策略的配对测试已经开始，但可能会出现更多根除HIV的障碍。尽管如此，仍有理由感到乐观，长效抗逆转录病毒疗法和HIV预防策略的进展将有助于HIV治愈研究工作，并且这些工作的实施将协同发挥作用，显著减轻HIV大流行对社会的影响。
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