铜-H 催化中 C=C 官能化和 C=O 还原的平衡。
Balancing C=C Functionalization and C=O Reduction in Cu-H Catalysis.
机构信息
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 115, 10623, Berlin, Germany.
出版信息
Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12148-9. doi: 10.1002/anie.201606701. Epub 2016 Aug 4.
PMID:27490748
Abstract
Coppercabana: The copper(I) hydride catalyzed functionalization of unactivated alkenes has been shown to be compatible with conventional carbonyl reduction. Through the combination of both pathways or complete suppression of C=O reduction in favor of C=C functionalization, methods for the stereoselective synthesis of a variety of chiral molecules have been developed.
摘要
铜卡巴纳
铜（I）氢化物催化的未活化烯烃的功能化已被证明与传统的羰基还原兼容。通过两种途径的结合或完全抑制 C=O 还原有利于 C=C 功能化，可以开发出各种手性分子的立体选择性合成方法。
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