恩格列净的燃料假说：言之尚早。
Empagliflozin's Fuel Hypothesis: Not so Soon.
机构信息
Cardiovascular Translational Science Institute, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Division of Cardiac Surgery, Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, ON M5S, Canada.
出版信息
Cell Metab. 2016 Aug 9;24(2):200-2. doi: 10.1016/j.cmet.2016.07.018.
The EMPA-REG OUTCOME trial (Zinman et al., 2015) established cardioprotective effects of empagliflozin in high-risk diabetic patients, but the underlying mechanisms remain elusive. A recent hypothesis proposed that increased ketone oxidation contributed to the effect, but several caveats indicate that the role of myocardial ketone oxidation is far from clear.
EMPA-REG OUTCOME 试验（Zinman 等人，2015 年）证实了恩格列净在高危糖尿病患者中的心脏保护作用，但潜在机制仍不清楚。最近提出的一个假设是，酮体氧化的增加促成了这种作用，但有几个注意事项表明，心肌酮体氧化的作用远未明确。
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