测量变应性鼻炎患者下鼻甲鼻黏膜局部免疫球蛋白 E。

Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.

机构信息

Department of Otorhinolaryngology, Toho University Sakura Medical Center, Chiba, Japan.

出版信息

Allergol Int. 2016 Oct;65(4):396-399. doi: 10.1016/j.alit.2016.03.009. Epub 2016 Aug 8.

DOI:10.1016/j.alit.2016.03.009

PMID:27516133

Abstract

BACKGROUND

Studies show that immunoglobulin E (IgE) is produced in the local nasal mucosa in allergic rhinitis patients. However, no study involved the measurement of IgE levels in the local nasal mucosal tissue in allergic rhinitis patients. This study aimed to measure the local IgE levels in the nasal mucosal tissue and to compare the levels of total IgE and specific IgEs in the serum and the inferior turbinate nasal mucosa in allergic rhinitis patients using the AlaSTAT 3gAllergy assay (Siemens Healthcare Diagnostics AG, Erlangen, Germany).

METHODS

Total IgE antibodies and allergen-specific IgE antibodies in each sample of nasal mucosal tissue from 11 allergic rhinitis patients were measured with the AlaSTAT 3gAllergy assay. We compared the levels of total IgE and IgEs specific for house dust (HD), mites, and cedar pollen in the serum and the inferior turbinate.

RESULTS

The total IgE levels and the cedar pollen-specific IgE levels in the inferior turbinate mucosal tissue correlated significantly with their respective levels in serum. The HD- and mite-specific IgE levels in the inferior turbinate mucosal tissue did not correlate significantly with their respective levels in the serum.

CONCLUSIONS

Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE.

摘要

背景

研究表明，变应性鼻炎患者的 IgE（免疫球蛋白 E）是在局部鼻黏膜中产生的。然而，尚无研究涉及变应性鼻炎患者局部鼻黏膜组织中 IgE 水平的测量。本研究旨在使用 AlaSTAT 3gAllergy 测定法（德国西门子医疗诊断公司）测量鼻黏膜组织中的局部 IgE 水平，并比较变应性鼻炎患者血清和下鼻甲鼻黏膜中总 IgE 和特异性 IgE 的水平。