免疫功能正常患者的微孢子虫性基质性角膜炎和眼内炎
Microsporidial stromal keratitis and endophthalmitis in an immunocompetent patient.
作者信息
Sood Arjun B, Debiec Matthew R, Yeh Steven, Grossniklaus Hans E, Randleman J Bradley
机构信息
Department of Ophthalmology, Emory University, Atlanta, GA, USA.
Emory Eye Center, Atlanta, GA, USA.
出版信息
J Ophthalmic Inflamm Infect. 2016 Dec;6(1):30. doi: 10.1186/s12348-016-0099-7. Epub 2016 Sep 1.
PURPOSE
The purpose of this study is to report a case of microsporidial endophthalmitis after penetrating keratoplasty in a healthy patient and discuss the management.
METHODS
This is a case report.
RESULTS
A 69-year-old healthy male underwent penetrating keratoplasty for corneal scar secondary to herpes stromal keratitis. He presented with features of acute graft rejection 3 years later. After failure of medical management, a repeat full thickness keratoplasty was performed. Pathologic examination of the corneal specimen showed microsporidia. The patient then developed a chronic endophthalmitis, and a vitreous tap and injection followed by pars plana vitrectomy were performed. Pathologic examination of tissue showed microsporidia.
CONCLUSIONS
Microsporidia are being increasingly identified as the cause of stromal keratitis. This is the first report of microsporidial endophthalmitis in a patient without underlying systemic illness.
目的
本研究旨在报告一例健康患者穿透性角膜移植术后发生微孢子虫性眼内炎的病例并讨论其治疗方法。
方法
这是一例病例报告。
结果
一名69岁健康男性因疱疹性基质性角膜炎继发角膜瘢痕接受穿透性角膜移植术。3年后，他出现急性移植排斥反应的症状。药物治疗失败后，再次进行了全层角膜移植术。角膜标本的病理检查显示有微孢子虫。随后该患者发生了慢性眼内炎，进行了玻璃体穿刺注药，随后行玻璃体切除术。组织病理检查显示有微孢子虫。
结论
微孢子虫越来越多地被确认为基质性角膜炎的病因。这是首例无潜在全身性疾病患者发生微孢子虫性眼内炎的报告。
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