不丹家禽中出现的高致病性重配甲型禽流感病毒（H5N1）2.3.2.1a分支毒株
Highly Pathogenic Reassortant Avian Influenza A(H5N1) Virus Clade 2.3.2.1a in Poultry, Bhutan.
作者信息
Marinova-Petkova Atanaska, Franks John, Tenzin Sangay, Dahal Narapati, Dukpa Kinzang, Dorjee Jambay, Feeroz Mohammed M, Rehg Jerold E, Barman Subrata, Krauss Scott, McKenzie Pamela, Webby Richard J, Webster Robert G
出版信息
Emerg Infect Dis. 2016 Dec;22(12):2137-2141. doi: 10.3201/eid2212.160611. Epub 2016 Dec 15.
Highly pathogenic avian influenza A(H5N1), clade 2.3.2.1a, with an H9-like polymerase basic protein 1 gene, isolated in Bhutan in 2012, replicated faster in vitro than its H5N1 parental genotype and was transmitted more efficiently in a chicken model. These properties likely help limit/eradicate outbreaks, combined with strict control measures.
2012年在不丹分离出的具有H9样聚合酶碱性蛋白1基因的高致病性甲型禽流感病毒（H5N1），进化分支2.3.2.1a，在体外比其H5N1亲本基因型复制更快，并且在鸡模型中传播效率更高。结合严格的控制措施，这些特性可能有助于限制/根除疫情爆发。
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