组织环境中的免疫系统在损伤后恢复稳态：“炎症” 总是炎症吗？
The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?
作者信息
Kulkarni Onkar P, Lichtnekert Julia, Anders Hans-Joachim, Mulay Shrikant R
机构信息
Department of Pharmacy, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Hyderabad 500078, India.
Medizinische Klinik und Poliklinik IV, Klinikum der Ludwig-Maximilians Universität München, 80336 Munich, Germany.
出版信息
Mediators Inflamm. 2016;2016:2856213. doi: 10.1155/2016/2856213. Epub 2016 Aug 11.
Inflammation is a response to infections or tissue injuries. Inflammation was once defined by clinical signs, later by the presence of leukocytes, and nowadays by expression of "proinflammatory" cytokines and chemokines. But leukocytes and cytokines often have rather anti-inflammatory, proregenerative, and homeostatic effects. Is there a need to redefine "inflammation"? In this review, we discuss the functions of "inflammatory" mediators/regulators of the innate immune system that determine tissue environments to fulfill the need of the tissue while regaining homeostasis after injury.
炎症是对感染或组织损伤的一种反应。炎症曾依据临床体征来定义，后来依据白细胞的存在来定义，如今则依据“促炎”细胞因子和趋化因子的表达来定义。但白细胞和细胞因子往往具有相当的抗炎、促再生和稳态维持作用。是否有必要重新定义“炎症”呢？在本综述中，我们讨论了先天性免疫系统的“炎症”介质/调节因子的功能，这些介质/调节因子决定组织环境，以满足组织的需求，同时在损伤后恢复内环境稳态。
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